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首页> 外文期刊>Journal of Cellular Physiology >Activated ERK/FOXM1 Pathway by Low-Power Laser Irradiation Inhibits UVB-Induced Senescence Through Down-Regulating p21 Expression
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Activated ERK/FOXM1 Pathway by Low-Power Laser Irradiation Inhibits UVB-Induced Senescence Through Down-Regulating p21 Expression

机译：低功率激光激活ERK / FOXM1通路辐照抑制UVB-Induced衰老通过显示p21表达

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摘要

Cellular senescence is a growth-arrest program that limits cell proliferation. Low-power laser irradiation (LPLI) has been demonstrated to promote cell proliferation. However, whether LPLI can inhibit celiular senescence remains unknown. In the present study, to investigate the functional role of LPLI against skin aging, we used ultraviolet radiation b (UVB) to induce cell senescence. We first report that LPLI can delay UVB-induced cell senescence. The senescence-associated p-galactosidase (SA-beta-Gal) activity and p21 expression, hallmarks of senescent cells, were decreased in the Forkhead box transcription factor FOXMI-dependent manner under treatment with LPLI. The effect of LPLI was further enhanced with an overexpression of FOXM I, and abolished when FOXMI was knockdown with short hairpin RNA (shRNA). Furthermore, LPLI activated the extracellular regulated protein kinases (ERK) that was upstream of FOXMI. This led to FOXMI phosphorylation and nuclear translocation. Nuclear translocation enhanced FOXH I transcriptional activity and promoted its downstream target gene c-Myc expression that could inhibit p21 expression. These findings highlight the protective effects of ERK/FOXMI pathway against UVB-induced cell senescence, suggesting a potential protecting strategy for treating skin aging by LPLI.
机译：细胞衰老是一个growth-arrest程序这限制了细胞增殖。辐照(LPLI)已经证明促进细胞增殖。可以抑制celiular衰老仍然未知。在目前的研究中,调查功能性LPLI对抗皮肤老化的作用,我们使用紫外线b (UVB)诱导细胞衰老。UVB-induced细胞衰老。senescence-associated p-galactosidase(SA-beta-Gal)活动和p21表达,衰老细胞的标志,是减少的Forkhead框转录因子FOXMI-dependent方式与LPLI接受治疗。LPLI进一步提升为的影响FOXM我的过度表达,和废除FOXMI与短发卡RNA击倒(成分)。细胞外调节蛋白激酶(ERK)这是FOXMI的上游。磷酸化和核易位。核易位增强FOXH我并提升其转录活动下游靶基因原癌基因表达可以抑制p21的表达。突出ERK / FOXMI的保护作用途径对UVB-induced细胞衰老,显示一个潜在的保护策略由LPLI治疗皮肤老化。

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