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首页> 外文期刊>Journal of Cellular Physiology >Telomere length maintenance, shortening, and lengthening
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Telomere length maintenance, shortening, and lengthening

机译：缩短端粒长度的维护,延长

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摘要

Telomeres maintain chromosome stability and cell replicative capacity. Telomere shortening occurs concomitant with aging. Short telomeres are associated with some diseases, such as dyskeratosis congenita, idiopathic pulmonary fibrosis, and aplastic anemia. Telomeres are longer in pluripotent stem cells than in somatic cells and lengthen significantly during preimplantation development. Furthermore, telomere elongation during somatic cell reprogramming is of great importance in the acquisition of authentic pluripotency. This review focuses primarily on regulatory mechanisms of telomere length maintenance in pluripotent cells, telomere length extension in early embryo development, and also telomere rejuvenation in somatic cell reprogramming. Telomere related diseases are also discussed in this review.
机译：端粒维持染色体稳定性和细胞复制的能力。伴随老化。与某些疾病有关,如角化病congenita,特发性肺纤维化、再生障碍性贫血。再在多能干细胞比在体细胞细胞和显著延长胚胎植入前的发展。在体细胞端粒延长重组是非常重要的获取真实的多能性。审查主要集中于监管机制多能的端粒长度的维护在早期胚胎细胞中,端粒长度延伸发展,以及端粒复兴体细胞重编程。疾病也是本文中讨论。

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