Quantifying mitotic chromosome dynamics and positioning

BissonetteS.; StumpffJ.

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Quantifying mitotic chromosome dynamics and positioning

机译：将有丝分裂染色体动力学和量化定位

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The proper organization and segregation of chromosomes during cell division is essential to the preservation of genomic integrity. To understand the mechanisms that spatially control the arrangement and dynamics of mitotic chromosomes requires imaging assays to quantitatively resolve their positions and movements. Here, we will discuss analytical approaches to investigate the position-dependent control of mitotic chromosomes in cultured cells. These methods can be used to dissect the specific contributions of mitotic proteins to the molecular control of chromosome dynamics.

机译：适当的组织和隔离染色体在细胞分裂过程中是至关重要的基因组完整性的保护。了解空间的机制控制有丝分裂的安排和动力学染色体需要成像分析定量地解决他们的立场和运动。方法调查位置相关控制培养细胞的有丝分裂染色体。这些方法可以用来解剖具体有丝分裂蛋白的贡献染色体动力学的分子控制。

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来源
《Journal of Cellular Physiology》 |2014年第10期|1301-1305|共5页
作者
BissonetteS.; StumpffJ.;
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作者单位

Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, United;

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原文格式 PDF
正文语种英语
中图分类
关键词
Chromosomes; Quantify; Cell DivisionChromosome SegregationMitotic ChromosomeLexical permutation sorting;

机译：染色体;量化;细胞DivisionChromosomeSegregationMitotic ChromosomeLexical排列排序;

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Quantifying mitotic chromosome dynamics and positioning

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