Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC-1α Through Different Transcription Factors

Gavaldà-NavarroA.; VillenaJ.A.; PlanavilaA.Vi?asO.MampelT.

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Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC-1α Through Different Transcription Factors

机译：腺嘌呤核苷酸移位酶的表达(蚂蚁)同种型基因是由PGC-1α不同的转录因子

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Adenine nucleotide translocase (ANT) isoforms are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in the cytosol. The aim of this study was to determine the role of the transcriptional coactivator PGC-1α (peroxisome proliferator-activated receptor-γ [PPAR-γ] coactivator 1α), a master regulator of mitochondrial oxidative metabolism, in the regulation of the expression of ANT isoform genes and to identify the transcription factors involved. We found that PGC-1α overexpression induced the expression of all ANT human and mouse isoforms but to different degrees. The transcription factor ERRα was involved in PGC-1α-induced expression of all human ANT isoforms (hANT1-3) in HeLa cells as well as in the regulation of mouse isoforms (mANT1-2) in C2C12 myotubes and 3T3-L1 adipocytes, even though ANT isoforms have important physiological differences and are regulated in a tissue-specific manner. In addition to ERRα, PPARδ and mTOR pathways were involved in the induction of mANT1-2 by PGC-1α in C2C12 myotubes, while PPARγ was involved in PGC-1α-regulation of mANT1-2 in 3T3-L1 adipocytes. Furthermore, the regulation of mANT genes by PGC-1α was also observed in vivo in knockout mouse models lacking PGC-1α. In summary, our results show that the regulation of genes encoding ANT isoforms is controlled by PGC-1α through different transcription factors depending on cell type. J. Cell. Physiol. 229: 2126-2136, 2014.

机译：腺嘌呤核苷酸移位酶(ANT)亚型线粒体蛋白质由核DNA编码催化ATP生成的交换线粒体ADP胞液中产生。本研究的目的是确定这个角色的转录辅激活PGC-1α(过氧物酶体proliferator-activated受体-γ(PPAR -γ)共激活剂1α),主调节器线粒体氧化代谢的监管的蚂蚁同种型基因的表达和识别转录因子参与。诱导表达的所有蚂蚁人类和老鼠亚型,但不同程度。转录因子犯错α是参与人类所有蚂蚁PGC-1全身的α的表达在海拉细胞亚型(hANT1-3)以及鼠标的规定亚型(mANT1-2)C2C12肌管和3 t3-l1脂肪细胞,尽管蚂蚁亚型具有重要的生理差异和监管组织的方式。PPARδ和mTOR通路参与了感应的mANT1-2 PGC-1α在C2C12肌管,虽然PPARγ参与PGC-1α监管3 t3-l1 mANT1-2脂肪细胞。mANT基因的调控PGC-1α也基因敲除小鼠模型的体内观察缺乏PGC-1α。调节基因编码ANT亚型通过不同控制PGC-1α转录因子取决于细胞类型。细胞。

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《Journal of Cellular Physiology》 |2014年第12期|2126-2136|共11页
作者
Gavaldà-NavarroA.; VillenaJ.A.; PlanavilaA.Vi?asO.MampelT.;
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作者单位

Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Institut de Biomedicina de la;

Laboratory of Metabolism and Obesity, Vall d'Hebron-Institut de Recerca, Uni. Autonoma de Barcelona;

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正文语种英语
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Transcription Factors; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein IsoformsAdenine Nucleotide TranslocaseRegulation (biology)Cell RespirationAerobiosisMitochondrial Proteinsmyotubenuclear genomeMitochondria;

机译：转录因子、过氧物酶体Proliferator-Activated受体γ共激活剂1-alpha;蛋白IsoformsAdenine核苷酸TranslocaseRegulation(生物学)细胞RespirationAerobiosisMitochondrialProteinsmyotubenuclear genomeMitochondria;

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Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC-1α Through Different Transcription Factors

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