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首页> 外文期刊>Journal of Cellular Physiology >Role of the extracellular matrix in whole organ engineering
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Role of the extracellular matrix in whole organ engineering

机译：细胞外基质的作用在整个器官工程

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摘要

End-stage organ failure is a devastating problem with limited therapeutic options. The definitive treatment is orthotropic transplantation, however, there exists a severe shortage of viable donor organs, and this shortage is worsening with an aging demographic and as the number of new cases of organ failure increases. Patients fortunate enough to receive a transplant are required to receive immunosuppressive therapies and can face transplant rejection. The emerging concept of organ engineering may offer a new hope for these patients. Researchers in the field of regenerative medicine and tissue engineering are using three-dimensional whole organ scaffolds composed of allogeneic or xenogeneic extracellular matrix (ECM) for engineering functional tissue suitable for transplantation. Perfusion decellularization is an approach that generates native ECM scaffolds with intact 3D anatomical architecture and vasculature. Decellularized organs provide the ideal transplantable scaffold with all the necessary microstructure and extracellular cues for cell attachment, differentiation, vascularization, and function. The present manuscript will review the role of the ECM in normal development, the concept of ECM tissue specificity, and the effect of processing methods on eventual clinical outcomes. An overview of existing challenges and future directions will also be discussed.
机译：终末期器官衰竭是一个严重的问题有限的治疗选择。治疗方法是正交的移植,然而,存在一个严重短缺的可行捐献器官,这恶化了短缺老龄化人口和新增器官衰竭病例增加。幸运地接受移植需要接受免疫抑制治疗面部移植排斥。器官工程学的概念可能提供一个新的希望对于这些病人。再生医学和组织工程使用三维整体器官支架同种异体或异种的组成细胞外基质(ECM)的工程功能性组织适合移植。灌注去细胞是一个方法生成本地ECM支架与完整的3 d解剖结构和脉管系统。脱细胞器官提供了理想的移植与所有必要的脚手架组织和细胞的细胞外信号附件、分化、血管化和函数。ECM的作用在正常发展,ECM的概念组织特异性和效果最终的临床处理方法结果。未来的发展方向也将被讨论。

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