AKT as locus of cancer angiogenic robustness and fragility

RadisavljevicZ.

首页> 外文期刊>Journal of Cellular Physiology >AKT as locus of cancer angiogenic robustness and fragility

【24h】

AKT as locus of cancer angiogenic robustness and fragility

机译：一种蛋白激酶作为肿瘤血管生成的轨迹的鲁棒性脆弱

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Angiogenesis get full robustness in metastatic cancer, relapsed leukemia or lymphoma when complex positive feedback loop signaling systems become integrative. A cancer hypoxic microenvironment generates positive loops inducing formation of the vascular functional shunts. AKT is an upstream angiogenic locus of integrative robustness and fragility activated by the positive loops. AKT controls two downstream nodes the mTOR and NOS in nodal organization of the signaling genes. AKT phosphorylation is regulated by a balance of an oxidant/antioxidant. Targeting AKT locus represents new principle to control integrative angiogenic robustness by the locus chemotherapy.

机译：血管生成在转移性获得完整的鲁棒性癌症复发白血病或淋巴瘤复杂的正反馈循环信号系统成为一体。微环境产生积极的循环诱导形成的血管功能分流术。综合鲁棒性和脆弱性激活积极的循环。节点的mTOR和节点组织中NOS信号的基因。由氧化/抗氧化的一个平衡。针对AKT轨迹代表新原则控制综合血管生成的鲁棒性轨迹化疗。

著录项

来源
《Journal of Cellular Physiology》 |2013年第1期|21-24|共4页
作者
RadisavljevicZ.;
展开▼
作者单位

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Leukemia; Lymphoma; Robustnessmetastatic cancerFragilityAngiogenesis;

机译：cancerFragilityAngiogenesis;

相似文献

外文文献
中文文献
专利

1. ONYCHIUM FRAGILE VERSUS ONYCHIUM TENUIFRONS REVISITED UPHOLDING THE IDENTITY OF ONYCHIUM FRAGILE [J] . S P KHULLAR, S C VERMA, GANGMTN ZHANG, Indian Fern Journal . 2011,第1a2期

机译：Onychium fragile对比yonchium tenuifrons重新强调了Onychium fragile的身份
2. Leitlinien zur molekulargenetischen Diagnostik: Fragiles-X und Fragiles-X assoziiertes Tremor/Ataxie Syndrom [J] . P. Steinbach, und D. Gl?ser Medizinische Genetik . 2009,第2期

机译：分子遗传学诊断指南：Fragiles-X和Fragiles-X相关的震颤/共济失调综合征
3. Retraction: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway by Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Jian Xu, Jian Zhao, Jinghui Bai, Xiaohui Su [J] . Cell biology international. . 2019,第12期

机译：Retraction: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway by Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Jian Xu, Jian Zhao, Jinghui Bai, Xiaohui Su
4. Seismic fragility analysis based on 3P-lognormal distribution Part 2 Numerical examples [C] . Fang-Wen Ge, Yan-Gang Zhao 日本建築学会大会;日本建築学会 . -1

机译：Seismic fragility analysis based on 3P-lognormal distribution Part 2 Numerical examples
5. The Roles of Akt1 and Akt2 Downstream of Src Family Kinases in the Migration and Invasion of Breast Cancer Cells. [D] . Chiueh, Venice Calinisan. 2010

机译：Src家族激酶下游的Akt1和Akt2在乳腺癌细胞迁移和侵袭中的作用。
6. Correction to: Cancer Biother Radiopharm 2014;29(8):303–309. DOI: 10.1089/cbr.2014.1653 and Cancer Biother Radiopharm 2014;29(10):451–456. DOI: 10.1089/cbr.2014.1698 [O] . -1

机译：更正为：Cancer Biother Radiopharm 2014; 29（8）：303-309。 DOI：10.1089 / cbr.2014.1653和Cancer Biother Radiopharm 2014; 29（10）：451–456。 DOI：10.1089 / cbr.2014.1698
7. Retraction: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway by Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Jian Xu, Jian Zhao, Jinghui Bai, Xiaohui Su [O] . 2019

机译：Retraction: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway by Rui Zhang, Jibin Li, Xiaofei Yan, Keer Jin, Wenya Li, Jian Xu, Jian Zhao, Jinghui Bai, Xiaohui Su
8. Tratamiento para el Cancer de Prostata: Guia para Hombres con Cancer Localizado de Prostata (Treating Prostate Cancer: A Guide for Men with Localized Prostate Cancer). [R] . 2008

机译：Tratamiento para el Cancer de prostata：Guia para Hombres con Cancer Localizado de prostata（治疗前列腺癌：患有局部前列腺癌的男性指南）。

AKT as locus of cancer angiogenic robustness and fragility

摘要

著录项

相似文献

相关主题

期刊订阅