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首页> 外文期刊>Journal of Cellular Physiology >Autophagy and ionizing radiation in tumors: The 'survive or not survive' dilemma
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Autophagy and ionizing radiation in tumors: The 'survive or not survive' dilemma

机译：自噬在肿瘤和电离辐射:“生存或无法生存”的困境

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Autophagy is a so-called "self-eating" system responsible for degrading long-lived proteins and cytoplasmic organelles, whose products are recycled to maintain cellular homeostasis. This ability makes autophagy a good candidate for a survival mechanism in response to several stresses, including the tumor cell transformation. In particular, recent studies suggested that autophagy functions as a pro-death mechanism within different tumor contexts. It is, however, widely reported that autophagy represents both a survival mechanism or contributes directly to cell death fate. This interplay of the autophagy functions has been observed in many types of cancers and, in some cases, autophagy has been demonstrated to both promote and inhibit antitumor drug resistance. From a therapeutical point of view, the effects of the modulation of the tumor cell autophagic status, in response to ionizing radiations, are presently of particular relevance in oncology. Accordingly, this review also provides a perspective view on future works for exploring the modulation of autophagic indices in tumor cells as a novel molecular-based adjuvant strategy, in order to improve radiotherapy and chemotherapy effects in cancer patients.
机译：自噬是一个所谓的“自食”系统负责降解蛋白质和健康长寿胞质细胞器,其产品回收维持细胞内稳态。才能使自噬一个好的候选人生存机制,以应对一些压力,包括肿瘤细胞转换。表明自噬功能的赞成在不同的肿瘤上下文机制。然而,自噬的广泛报道或者是一种生存机制直接有助于细胞死亡的命运。自噬功能的相互作用在许多类型的癌症,在某些情况下,自噬被证明促进和抑制抗肿瘤耐药。从治疗的角度来看,影响调制的肿瘤细胞自噬状态、应对电离辐射目前肿瘤的特殊的意义。因此,本文还提供了一个角度看待未来的探索工作自噬在肿瘤指标的调制细胞作为一种新型分子佐剂策略,为了提高放疗和在癌症患者化疗效果。

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