Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

JungJ.-Y.; OhJ.-H.; LeeD.H.LeeS.ChungJ.H.

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Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

机译：B血型抗原调节细胞迁移通过调节cdc42表达式和活动在HaCaT细胞

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ABO blood group is determined by carbohydrate antigens, called ABH antigens. It has been known that the change of carbohydrate antigen expression, including ABH antigens, has correlation with the tumor metastasis and survival; however, the exact mechanism remains to be elucidated. ABH antigens are expressed not only in blood cells but also in several tissues. In epidermis, ABH antigen is expressed in the uppermost spinous and granular layer. We investigated the role of ABH antigens on the cell migration of HaCaT keratinocytes, which express B antigen. Knock-down of B antigen expression by small interference RNA of FUT1 inhibited HaCaT cell migration. At that time, we found that lamellipodia and actin fiber were also reduced by knock-down of B antigen expression. The transcription of cdc42, a kind of Rho GTPase which plays a key role in actin polymerization, was reduced by down-regulated B antigen expression. Furthermore, the reduced B antigen expression also inhibited the interaction of cdc42 and N-WASP. Collectively, our data provide a clue how ABH antigens regulate the cell migration mechanism.

机译：ABO血型是由碳水化合物抗原,叫做ABH抗原。碳水化合物抗原的变化表达式,包括ABH抗原与肿瘤转移相关生存而生存;被阐明。只有在血细胞还在多个组织。在表皮,ABH抗原的表达的尖尖的和颗粒层。调查ABH抗原在细胞的作用迁移HaCaT角质细胞,表达B抗原。FUT1抑制HaCaT的小干扰RNA细胞迁移。板状伪足和肌动蛋白纤维也减少了可拆卸的B抗原表达。转录cdc42,ρGTPase在肌动蛋白聚合中发挥着关键作用,降低了抑制B抗原表达式。也表达抑制的相互作用cdc42 N-WASP。一个线索ABH抗原如何调节细胞迁移机制。

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来源
《Journal of Cellular Physiology》 |2013年第11期|2243-2251|共9页
作者
JungJ.-Y.; OhJ.-H.; LeeD.H.LeeS.ChungJ.H.;
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作者单位

Department of Dermatology, Seoul National University College of Medicine, Medical Research Center;

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正文语种英语
中图分类细胞生物学;
关键词
antigen expression; HaCat cell line; blood group ABH antigenFUT1 geneNeoplasm MetastasisCell MigrationB AntigenCell Locomotionactin polymerization;

机译：抗原表达;HaCat细胞系;血型ABHantigenFUT1 geneNeoplasm MetastasisCellMigrationB AntigenCell Locomotionactin聚合;

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Blood Type B antigen modulates cell migration through regulating cdc42 expression and activity in HaCaT cells

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