Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells

StrianeseM.; BasileA.; MazzoneA.MorelloS.TurcoM.C.PellecchiaC.

首页> 外文期刊>Journal of Cellular Physiology >Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells

【24h】

Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells

机译：pyridoxal-based的治疗潜力钒(IV)复杂的选择性为癌症和健康细胞细胞毒性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Vanadium compounds can exert anticancer effects, partly due to inhibition of tyrosine phosphatases. Here, we report the effect of N,N′-ethylenebis (pyridoxylideneiminato) vanadium (IV) complex (Pyr2enV(IV)), that induced 93% and 57% of cell mortality in A375 (human melanoma) and A549 (human lung carcinoma) cells, respectively; the mortality was 24% in other cancer cell lines and in human normal epidermal keratinocytes, lung cells and peripheral blood mononuclear cells. The mechanism of Pyr2enV(IV) effect relied on apoptosis induction; this was triggered by ROS increase, followed by mitochondrial membrane depolarization. Indeed, the addition of N-acetyl cysteine to cell cultures abated Pyr2enV(IV)-induced apoptosis. These results disclose the pro-apoptotic activity of Pyr2enV(IV) and its mechanism, relying on intracellular ROS increase.

机译：钒化合物能起到抗癌作用,部分原因是抑制酪氨酸磷酸酶。(四)复杂(Pyr2enV (IV)),诱导和93%黑色素瘤A375细胞死亡率的57%(人类)和人类肺癌A549细胞,分别;癌症细胞系和人类正常的表皮角化细胞、肺癌细胞和外周血单核细胞。效果依赖于细胞凋亡诱导;引发活性氧增加,紧随其后线粒体膜去极化。n -乙酰半胱氨酸的细胞文化减弱Pyr2enV (IV)全身的细胞凋亡。这些结果披露pro-apoptotic活动Pyr2enV (IV)及其机制,依赖细胞内ROS增加。

著录项

来源
《Journal of Cellular Physiology》 |2013年第11期|2202-2209|共8页
作者
StrianeseM.; BasileA.; MazzoneA.MorelloS.TurcoM.C.PellecchiaC.;
展开▼
作者单位

Department of Pharmacy and BIOUNIVERSA s.r.l., University of Salerno, via Ponte Don Melillo;

Department of Medicine and Surgery, University of Salerno, Via S. Allende, Baronissi (SA), Italy;

Department of Chemistry and Biology, University of Salerno, Via Ponte Don Melillo, Fisciano (SA),;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Protein Tyrosine Phosphatases; Alveolar Epithelial Cells; Carcinoma of LungAcetylcysteineCytotoxicityCancerPositive Regulation of Apoptosisperipheral blood mononuclear cellcancer cell culturevanadium compounds;

机译：蛋白质酪氨酸磷酸酶;肺泡上皮细胞;癌LungAcetylcysteineCytotoxicityCancerPositive监管Apoptosisperipheral血单核细胞cellcancer culturevanadium化合物;

相似文献

外文文献
中文文献

1. Emerging data supporting stromal cell therapeutic potential in cancer:reprogramming stromal cells of the tumor microenvironment for anti-cancer effects [J] . Armel H.Nwabo Kamdje, Paul F.Seke Etet, Richard Tagne Simo, 癌症生物学与医学：英文版 . 2020,第004期
2. Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects [J] . Armel H. Nwabo Kamdje, Paul F. Seke Etet, Richard Tagne Simo, 癌症生物学与医学（英文版） . 2020,第004期
3. Relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value [J] . Mei Liu, Jue Wang 海南医科大学学报(英文版) . 2018,第020期
4. Relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value [J] . Mei Liu, Jue Wang 海南医科大学学报（英文版） . 2018,第020期
5. Stereotactic Ablative Radiotherapy versus Lobectomy for Operable Stage I Non-small-cell Lung Cancer: A Pooled Analysis of Two Randomized Trials——胸外科医生的解读 [O] . 许林 (Lin XU) 2015

机译：Stereotactic Ablative Radiotherapy versus Lobectomy for Operable Stage I Non-small-cell Lung Cancer: A Pooled Analysis of Two Randomized Trials——胸外科医生的解读
6. Roles of MKK1/2-ERK1/2 and Phosphoinositide 3-Kinase-AKT Signaling Pathways in Erlotinib-Induced Rad51 Suppression and Cytotoxicity in Human Non-Small Cell Lung Cancer Cells [O] . Ko, J.C., Ciou, S.C., Jhan, J.Y., 2014

机译：Roles of mKK1/2-ERK1/2 and phosphoinositide 3-Kinase-aKT signaling pathways in Erlotinib-Induced Rad51 suppression and Cytotoxicity in Human Non-small Cell Lung Cancer Cells

Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells

摘要

著录项

相似文献

相关主题

期刊订阅