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首页> 外文期刊>Journal of Cellular Physiology >Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
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Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

机译：函数和类黄酮的作用机制淫羊藿在调节浓度染料木黄酮和骨头重构

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Increasingly natural products particularly flavonoids are being explored for their therapeutic potentials in reducing bone loss and maintaining bone health. This study has reviewed previous studies on the two better known flavonoids, genistein and icariin, their structures, functions, action mechanisms, relative potency, and potential application in regulating bone remodeling and preventing bone loss. Genistein, an isoflavone abundant in soy, has dual functions on bone cells, able to inhibit bone resorption activity of osteoclasts and stimulate osteogenic differentiation and maturation of bone marrow stromal progenitor cells (BMSCs) and osteoblasts. Genistein is an estrogen receptor (ER)-selective binding phytoestrogen, with a greater affinity to ERβ. Genistein inhibits tyrosine kinases and inhibits DNA topoisomerases I and II, and may act as an antioxidant. Genistein enhances osteoblastic differentiation and maturation by activation of ER, p38MAPK-Runx2, and NO/cGMP pathways, and it inhibits osteoclast formation and bone resorption through inducing osteoclastogenic inhibitor osteoprotegerin (OPG) and blocking NF-κB signaling. Icariin, a prenylated flavonol glycoside isolated from Epimedium herb, stimulates osteogenic differentiation of BMSCs and inhibits bone resorption activity of osteoclasts. Icariin, whose metabolites include icariside I, icariside II, icaritin, and desmethylicaritin, has no estrogenic activity. However, icariin is more potent than genistein in promoting osteogenic differentiation and maturation of osteoblasts. The existence of a prenyl group on C-8 of icariin molecular structure has been suggested to be the reason why icariin is more potent than genistein in osteogenic activity. Thus, the prenylflavonoids may represent a class of flavonoids with a higher osteogenic activity.
机译：越来越多的天然产物尤其是类黄酮被探索的治疗在减少骨质流失和潜力维持骨骼健康。之前的研究在两个更好的认识类黄酮,淫羊藿,浓度染料木黄酮和他们结构、功能、作用机制,相对力量,和潜在的应用调节骨重塑和防止骨的损失。骨细胞具有双重功能,能抑制吗破骨细胞和骨吸收活动刺激成骨细胞的分化并成熟的骨髓基质祖细胞(bmsc)和成骨细胞。雌激素受体(ER)选择性绑定植物雌激素,具有更大的亲和力ERβ。染料木黄酮抑制酪氨酸激酶和抑制DNA拓扑异构酶I和II,可以作为一个抗氧化剂。被激活的分化和成熟呃,p38MAPK-Runx2,和NO / cGMP通路,它抑制破骨细胞形成和骨吸收通过诱导osteoclastogenic抑制剂osteoprotegerin(功能)和屏蔽NF -κB信号。糖苷淫羊藿隔绝,刺激成骨的bmsc的分化和抑制骨吸收的活动破骨细胞。desmethylicaritin,没有雌激素的活动。淫羊藿是浓度,比染料木素更有效促进成骨分化和成熟的成骨细胞。淫羊藿分子浓度prenyl小组8的结构被建议的原因icariin比染料木素更有效成骨的活动。可能代表一个类的类黄酮高成骨的活动。

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