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首页> 外文期刊>Journal of Cellular Physiology >Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice
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Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice

机译：益生菌使用减少肠道炎症并在健康男性但增加骨密度没有雌性老鼠

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Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease. Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease. Here, we examined if treating healthy male mice with Lactobacillus reuteri ATCC PTA 6475 (a candidate probiotic with anti-TNFα activity) could affect intestinal TNFα levels and enhance bone density. Adult male mice were given L. reuteri 6475 orally by gavage for 3×/week for 4 weeks. Examination of jejunal and ileal RNA profiles indicates that L. reuteri suppressed basal TNFα mRNA levels in the jejunum and ileum in male mice, but surprisingly not in female mice. Next, we examined bone responses. Micro-computed tomography demonstrated that L. reuteri 6475 treatment increased male trabecular bone parameters (mineral density, bone volume fraction, trabecular number, and trabecular thickness) in the distal femur metaphyseal region as well as in the lumbar vertebrae. Cortical bone parameters were unaffected. Dynamic and static histomorphometry and serum remodeling parameters indicate that L. reuteri ingestion increases osteoblast serum markers and dynamic measures of bone formation in male mice. In contrast to male mice, L. reuteri had no effect on bone parameters in female mice. Taken together our studies indicate that femoral and vertebral bone formation increases in response to oral probiotic use, leading to increased trabecular bone volume in male mice.
机译：骨质疏松症可以导致肠道炎症,与炎症性肠疾病。在摄取宿主的健康益处足够的数量,可以消炎属性和目前正在检查治疗炎症性肠病。检查如果治疗健康雄性老鼠这种乳酸菌写明ATCC PTA 6475(一位候选人益生菌与anti-TNFα活动)可能影响肠道肿瘤坏死因子α水平和增强骨密度。成年雄性老鼠这种l . 6475口头由填喂法为每周3×4周。空肠和回肠RNA资料表明,L。这种抑制基底肿瘤坏死因子α在mRNA水平空肠和回肠的雄性老鼠,但令人惊讶的是雌性老鼠。响应。这种l . 6475治疗增加男性(矿物质密度,骨小梁骨参数体积分数、小梁数目和在远端股骨小梁厚度)metaphyseal地区以及在腰椎椎骨。不受影响。和血清重构参数表明,L。这种摄入增加成骨细胞血清标记和动态骨形成的措施雄性老鼠。对雌性小鼠的骨参数没有影响。综上所述我们的研究表明,股和椎体骨形成增加对口服益生菌使用,导致在雄性老鼠骨小梁体积增加。

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