• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Adenosine, Adenosine Receptors and Their Role in Glucose Homeostasis and Lipid Metabolism
【24h】

Adenosine, Adenosine Receptors and Their Role in Glucose Homeostasis and Lipid Metabolism

机译：腺苷、腺苷受体及其作用葡萄糖稳态和脂质代谢

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adenosine is an endogenous metabolite that is released from all tissues and cells including liver, pancreas, muscle, and fat, particularly under stress, intense exercise, or during cell damage. The role of adenosine in glucose homeostasis has been attributed to its ability to regulate, through its membrane receptors, processes such as insulin secretion, glucose release and clearance, glycogenolysis, and glycogenesis. Additionally, adenosine and its multiple receptors have been connected to lipid metabolism by augmenting insulin-mediated inhibition of lipolysis, and the subsequent increase in free fatty acids and glycerol levels. Furthermore, adenosine was reported to control liver cholesterol synthesis, consequently affecting plasma levels of cholesterol and triglycerides, and the amount of adipose tissue. Alterations in the balance of glucose and lipid homeostasis have implications in both cardiovascular disease and diabetes. The ability of different adenosine receptors to activate and inhibit the same signaling cascades has made it challenging to study the influence of adenosine, adenosine analogs and their receptors on health and disease. This review focuses on the role and significance of different adenosine receptors in mediating the effect of adenosine on glucose and lipid homeostasis.
机译：腺苷是一种内源性代谢物从所有组织和细胞包括释放肝脏、胰腺、肌肉和脂肪,尤其是在压力之下,剧烈运动,或在细胞损害。体内平衡已被归因于能力调节,通过膜受体,过程如胰岛素分泌、葡萄糖释放和间隙、肝糖分解糖原生成。多个受体与脂质新陈代谢,增加insulin-mediated抑制脂类分解,随后游离脂肪酸和甘油浓度的增加。此外,据报道,腺苷的控制肝脏胆固醇的合成,因此影响血浆胆固醇和甘油三酸酯和脂肪组织的数量。改变平衡的葡萄糖和脂质体内平衡在这两方面都具有广泛的意义心血管疾病和糖尿病。不同的激活和腺苷酸受体抑制相同的信号级联了具有挑战性的研究腺苷的影响,腺苷类似物及其受体的健康和疾病。不同的腺苷酸受体的重要性调解在葡萄糖和腺苷的影响脂质稳态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号