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首页> 外文期刊>Journal of Cellular Physiology >Malignant mesothelioma: facts, myths, and hypotheses.
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Malignant mesothelioma: facts, myths, and hypotheses.

机译：恶性间皮瘤:事实、神话和假设。

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Malignant mesothelioma (MM) is a neoplasm arising from mesothelial cells lining the pleural, peritoneal, and pericardial cavities. Over 20 million people in the US are at risk of developing MM due to asbestos exposure. MM mortality rates are estimated to increase by 5-10% per year in most industrialized countries until about 2020. The incidence of MM in men has continued to rise during the past 50 years, while the incidence in women appears largely unchanged. It is estimated that about 50-80% of pleural MM in men and 20-30% in women developed in individuals whose history indicates asbestos exposure(s) above that expected from most background settings. While rare for women, about 30% of peritoneal mesothelioma in men has been associated with exposure to asbestos. Erionite is a potent carcinogenic mineral fiber capable of causing both pleural and peritoneal MM. Since erionite is considerably less widespread than asbestos, the number of MM cases associated with erionite exposure is smaller. Asbestos induces DNA alterations mostly by inducing mesothelial cells and reactive macrophages to secrete mutagenic oxygen and nitrogen species. In addition, asbestos carcinogenesis is linked to the chronic inflammatory process caused by the deposition of a sufficient number of asbestos fibers and the consequent release of pro-inflammatory molecules, especially HMGB-1, the master switch that starts the inflammatory process, and TNF-alpha by macrophages and mesothelial cells. Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM. J. Cell. Physiol. 227: 44-58, 2012. (c) 2011 Wiley Periodicals, Inc.
机译：恶性间皮瘤(MM)是一种肿瘤引起从胸膜壁层间皮的细胞,腹膜,心包腔。数百万美国人的风险发展中MM由于暴露于石棉。据估计,死亡率增加在大多数工业化国家每年5 - 10%直到大约2020年。继续上升在过去50年里,发病率在女性看来基本上保持不变。据估计,大约50 - 80%的胸膜毫米在男性和女性开发的20 - 30%个人的历史表明石棉从大多数暴露(s)高于预期背景设置。30%的男性腹膜间皮瘤与暴露于石棉有关。一个强有力的致癌矿物纤维的能力引起胸膜和腹膜毫米。毛沸石相当普遍低于石棉,MM案件联系在一起毛沸石敞口较小。DNA的改变主要是由诱导间皮的细胞和巨噬细胞分泌反应诱变的氧和氮物种。另外,石棉致癌有关造成的慢性炎症过程足够数量的石棉的沉积纤维和随之而来的释放炎性分子,特别是HMGB-1,主开关,启动炎症过程,由巨噬细胞和tnf间皮的细胞。辐射和病毒感染辅助因子,可以单独或一起石棉和毛沸石引起毫米。j .细胞。227: 44-58, 2012。公司。

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