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首页> 外文期刊>Journal of Cellular Physiology >Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells.
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Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells.

机译：系统生物学提供了新的见解分子机制控制的命运胚胎干细胞。

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摘要

During the last 5 years there has been enormous progress in developing a deeper understanding of the molecular mechanisms that control the self-renewal and pluripotency of embryonic stem cells (ESC). Early progress resulted from studying individual transcription factors and signaling pathways. Unexpectedly, these studies demonstrated that small changes in the levels of master regulators, such as Oct4 and Sox2, promote the differentiation of ESC. More recently, impressive progress has been made using technologies that provide a global view of the signaling pathways and the gene regulatory networks that control the fate of ESC. This review provides an overview of the progress made using several different high-throughput technologies and focuses on proteomic studies, which provide the first glimpse of the protein-protein interaction networks used by ESC. The latter studies indicate that transcription factors required for the self-renewal of ESC are part of a large, highly integrated protein-protein interaction landscape, which helps explain why the levels of master regulators need to be regulated precisely in ESC.
机译：在过去5年已经有巨大的进步在发展中更深层次的理解控制的分子机制自我更新和胚胎干细胞的多能性细胞(ESC)。单个转录因子和学习信号通路。证明小水平的变化主监管机构,如Oct4和Sox2,促进ESC的分化。令人印象深刻的进展技术提供的全局视图信号通路和基因调控网络控制ESC的命运。检查进展的概述使用几种不同的高通量技术和集中在蛋白质组学研究,提供的第一次看到吗蛋白质相互作用网络由ESC使用。后者研究表明,转录ESC的自我更新所需因素一个大的一部分,高度集成景观、蛋白质间交互作用有助于解释为什么主监管机构的水平在ESC需要精确调节。

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