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首页> 外文期刊>Journal of Cellular Physiology >CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells.
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CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells.

机译：CCN6增强ICAM-1表达和细胞的能动性在人类软骨肉瘤细胞。

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摘要

Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. CCN6 is a cysteine-rich protein that belongs to the CCN (Cyr61, CTGF, and Nov) family of matricellular proteins. However, the effects of CCN6 on human chondrosarcoma cells are largely unknown. In this study, we found that CCN6 increased the migration and the expression of intercellular adhesion molecule-1 (ICAM-1) in human chondrosarcoma cells. alphavbeta3 and alphavbeta5 integrin monoclonal antibody and mitogen-activated protein kinase (MEK) inhibitors (PD98059 and U0126) inhibited the CCN6-induced increase of the migration and ICAM-1 up-regulation of chondrosarcoma cells. CCN6 stimulation increased the phosphorylation of focal adhesion kinase (FAK), MEK, and extracellular signal-regulated kinase (ERK). In addition, activator protein-1 (AP-1) inhibitors suppressed the cell migration and ICAM-1 expression enhanced by CCN6. Moreover, CCN6 increased AP-1 luciferase activity and binding of c-Jun to the AP-1 element on the ICAM-1 promoter. Taken together, our results indicate that CCN6 enhances the migration of chondrosarcoma cells by increasing ICAM-1 expression through the alphavbeta3 and alphavbeta5 integrin receptor, FAK, MEK, ERK, c-Jun, and AP-1 signal transduction pathway.
机译：软骨肉瘤是一种高度恶性肿瘤以一种强有力的入侵本地和能力引起远处转移。偏爱转移到肺部。一个属于CCN cysteine-rich蛋白质(Cyr61 CTGF和11月)matricellular的家庭蛋白质。软骨肉瘤细胞在很大程度上是未知的。研究中,我们发现CCN6增加了迁移和细胞间粘附的表达人类软骨肉瘤molecule-1 (ICAM-1)细胞。单克隆抗体和增殖作用激酶(MEK)抑制剂(PD98059和U0126)抑制了CCN6-induced增加的迁移和ICAM-1老年病软骨肉瘤细胞。粘着斑激酶的磷酸化(FAK)、MEK和细胞外signal-regulated激酶(ERK)。(AP-1)抑制剂抑制细胞迁移并通过CCN6 ICAM-1表达增强。CCN6 AP-1荧光素酶活性和增加c-Jun AP-1元素的绑定ICAM-1启动子。表明CCN6提高迁移通过增加ICAM-1软骨肉瘤细胞通过alphavbeta3和表达式alphavbeta5 integrin receptor, FAK MEK ERK,c-Jun, AP-1信号转导通路。

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