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首页> 外文期刊>Journal of Cellular Physiology >JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy
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JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy

机译：负载在脑脊液和JC病毒转录控制区域重组预测进步的临床过程多病灶的脑白质病

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Progressive multifocal leukoencephalopathy (PML) is a severe disease of the central nervous system (CNS), caused by infection with the Polyomavirus JC virus (JCV). Because there are no known treatments or prognostic factors, we performed a long-term study focusing mainly on cerebrospinal fluid (CSF) samples from PML patients to describe the virological features akin to the different forms of the disease. Twenty-eight PML patients were enrolled: 10 HIV-1+ patients with classical PML (CPML), 9 HIV-1+ patients with slowly progressing or stable neurological symptoms (benign PML), 3 HIV-1+ asymptomatic patients, and 6 HIV-1-negative patients. CSF, urine, and blood samples were collected at the enrollment (baseline) and every 6 months afterwards when possible. The JCV DNA and HIV-1 RNA loads were determined, and the JCV strains were characterized. At baseline, the mean CSF JCV load was log6.0±1.2copies/ml for CPML patients, log4.0±1.0 copies/ml for benign PML patients, log4.2±0.5 copies/ml for asymptomatic PML patients, and log5.8±1.3copies/ml for HIV-1-negative PML patients (CPML vs. benign: P<0.01; CPML vs. asymptomatic: P<0.05; HIV-1 negative vs. benign: P<0.01). Organization of the JCV transcriptional control region (TCR) showed unusual archetype structures in two long-term survival patients; the NF1 sequence was found most commonly, whereas the Sp1 binding site was the most common for both CPML patients and HIV-1 negative patients. Our results suggest that the JCV load in the CSF and the organization of the TCR should be considered as indicators of PML clinical outcome. J. Cell. Physiol. 227: 3511-3517, 2012.
机译：渐进多焦点的脑白质病(PML)是一种严重的中枢神经系统疾病(中枢神经系统),由感染多瘤病毒引起的JC病毒(JCV)。治疗和预后因素,我们进行了长期研究主要关注脑脊髓流体(CSF)样本PML病人来描述病毒学特征类似于不同形式的疾病。患者为:10 hiv - 1 +经典吗PML (CPML), hiv - 1 + 9患者缓慢进展或稳定的神经症状PML(良性),3 hiv - 1 +无症状的病人,和6 HIV-1-negative病人。样本收集登记(基线),每6个月之后当可能的。决定,JCV菌株为特征。是log6.0±1.2拷贝/毫升CPML患者,log4.0±1.0拷贝/毫升良性PML的病人,为无症状的PML log4.2±0.5拷贝/毫升患者和log5.8±1.3拷贝/毫升HIV-1-negative PML患者(CPML与良性:P < 0.01;消极与良性:P < 0.01)。JCV转录控制区域(TCR)显示在两个长期不寻常的原型结构生存的病人;最常见的,而Sp1结合位点最常见的CPML患者和hiv - 1消极的病人。JCV负载的CSF和组织识别应考虑PML的指标临床结果。3511-3517, 2012.

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