Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

EliadesA.; MatsuuraS.; RavidK.

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Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

机译：氧化酶类和活性氧造血作用:专注于巨核细胞

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Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described. J. Cell. Physiol. 227: 3355-3362, 2012.

机译：活性氧(ROS)生成的作为结果各种反应,控制的数组细胞过程。巨核细胞(可)发展主题的兴趣和研究。是一个站点的可分化和成熟。在这种环境下,一个梯度的氧气紧张,normoxia缺氧导致不同级别的ROS,影响细胞生理机能。活性氧的主要来源,其含义不同的信号通路,和他们的影响细胞生理、关注megakaryopoiesis。在可生物学和ROS-generating氧化酶类病理,包括骨髓纤维化,也描述。2012.

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来源
《Journal of Cellular Physiology》 |2012年第10期|3355-3362|共8页
作者
EliadesA.; MatsuuraS.; RavidK.;
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作者单位

Department of Biochemistry, Boston University School of Medicine, Boston, MA, United States;

Department of Medicine, Boston University School of Medicine, Boston, MA, United States, Whitaker;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Oxidase; Megakaryocytes; Reactive Oxygen SpeciesOxidoreductasesBone Marrow FibrosesOxygen tensionHematopoiesisfocuses on;

机译：氧化酶、巨核细胞活性氧SpeciesOxidoreductasesBone骨髓FibrosesOxygen;

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Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes

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