Protein sequences involved in the mitochondrial import of the 3,5,3′-L-triiodothyronine receptor p43

CarazoA.; LevinJ.; CasasF.SeyerP.GrandemangeS.BussonM.PessemesseL.Wrutniak-CabelloC.CabelloG.

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Protein sequences involved in the mitochondrial import of the 3,5,3′-L-triiodothyronine receptor p43

机译：参与线粒体蛋白质序列进口的3、5、3 ' -L-triiodothyronine受体p43

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The major effect of T3 on mitochondrial activity has been partly explained by the discovery of p43, a T3-dependent transcription factor of the mitochondrial genome. P43 is imported into mitochondria in an atypical manner which is not yet fully understood. Our aim was to characterize the p43 sequences inducing its mitochondrial import, using in organello import experiments with wild-type or mutated proteins and validation in CV1 cells. We find that several sequences define the mitochondrial addressing. Two alpha helices in the C-terminal part of p43 are actual mitochondrial import sequences as fusion to a cytosolic protein induces its mitochondrial translocation. Helix 5 drives the atypical mitochondrial import process, whereas helices 10/11 induce a classical import process. However, despite its inability to drive a mitochondrial import, the N-terminal region of p43 also plays a permissive role as in the presence of the C-terminal import sequences different N-terminal regions determine whether the protein is imported or not. These results can be extrapolated to other mitochondrial proteins related to the nuclear receptor superfamily, devoid of classical mitochondrial import sequences.

机译：T3线粒体活动的重大影响已经被发现的原因之一吗p43, T3-dependent转录因子线粒体基因组。线粒体在一个并不是典型的方式然而完全理解。p43序列诱导线粒体进口,使用在organello导入实验野生型和突变蛋白质和验证在CV1细胞。定义了线粒体寻址。螺旋线的c端部分p43实际线粒体序列作为融合到一个导入胞质蛋白诱导的线粒体易位。线粒体导入过程,而螺旋10/11诱导古典导入过程。尽管它无法驱动的线粒体进口,p43也是一个氨基的地区宽容的作用的存在c端导入不同的n端序列区域确定蛋白质是进口的与否。其他线粒体蛋白质有关核受体超家族,缺乏古典线粒体导入序列。

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来源
《Journal of Cellular Physiology》 |2012年第12期|3768-3777|共10页
作者
CarazoA.; LevinJ.; CasasF.SeyerP.GrandemangeS.BussonM.PessemesseL.Wrutniak-CabelloC.CabelloG.;
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作者单位

UMR 866 Dynamique Musculaire et Métabolisme, INRA, Université Montpellier 1, Université Montpellier;

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正文语种英语
中图分类细胞生物学;
关键词
AIMP1 gene; Amino Acid Sequence; CV1 CELLSMitochondriaCarboxy-Terminal Amino AcidMitochondrial Proteins;

机译：AIMP1基因氨基酸序列;CV1CELLSMitochondriaCarboxy-Terminal氨基AcidMitochondrial蛋白质;

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Protein sequences involved in the mitochondrial import of the 3,5,3′-L-triiodothyronine receptor p43

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