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首页> 外文期刊>Journal of Cellular Physiology >Impact of testosterone on body fat composition
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Impact of testosterone on body fat composition

机译：睾丸激素在体内脂肪成分的影响

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An excessive food supply has resulted in an increasing prevalence of overweight and obesity, conditions accompanied by serious health problems. Several studies have confirmed the significant inverse correlation between testosterone and obesity. Indeed after decades of intense controversy, a consensus has emerged that androgens are important regulators of fat mass and distribution in mammals and that androgen status affects cellularity in vivo. The high correlation of testosterone levels with body composition and its contribution to the balance of lipid metabolism are also suggested by the fact that testosterone lowering is associated with important clinical disorders such as dyslipidemia, atherosclerosis, cardiovascular diseases, metabolic syndrome and diabetes. In contrast, testosterone supplementation therapy in hypogonadic men has been shown to improve the lipid profile by lowering cholesterol, blood sugar and insulin resistance. Leptin, ghrelin and adiponectin are some of the substances related to feeding as well as androgen regulation. Thus, complex and delicate mechanisms appear to link androgens with various tissues (liver, adipose tissue, muscles, coronary arteries and heart) and the subtle alteration of some of these interactions might be the cause of correlated diseases. This review underlines some aspects regarding the high correlations between testosterone physiology and body fat composition.
机译：食品供应过度导致了超重和肥胖的患病率增加,伴随着严重的健康条件问题。显著负相关关系睾酮和肥胖。激烈的争论,他们已经达成共识,雄激素脂肪量有重要的调控作用和分布在哺乳动物中,雄性激素状态会影响体内细胞结构。相关的睾丸激素水平与身体成分及其贡献的平衡脂质代谢也建议的睾酮降低相关联的事实等重要的临床疾病血脂异常、动脉粥样硬化、心血管疾病,代谢综合征和糖尿病。相反,睾酮补充治疗hypogonadic男人已经被证明可以改善通过降低胆固醇、血脂血糖和胰岛素抵抗。脂联素的物质有关喂养以及雄激素调节。复杂和微妙的机制似乎链接雄激素与各种组织(肝脏、脂肪组织、肌肉、冠状动脉和心脏)和其中的一些微妙的改变交互相关的可能原因疾病。关于高之间的相关性睾丸激素生理和身体脂肪成分。

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