High expression of ubiquitin conjugates and NF-kappaB in unstable human intracranial atherosclerotic plaques.

Sun R; Xiao L; Duan S

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High expression of ubiquitin conjugates and NF-kappaB in unstable human intracranial atherosclerotic plaques.

机译：高表达的泛素配合NF-kappaB人类颅内不稳定动脉粥样硬化斑块。

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Arteries from the first segment of the middle cerebral and adjacent normal blood vessel specimens were collected from 19 patients who had died from cerebral infarction. According to morphologic examination the atherosclerotic plaque present was classified as stable or unstable. The expression of ubiquitin conjugates and nuclear factor kappa B (NF-kappaB) was assessed and found significantly higher in plaques than normal tissue and higher in unstable plaques than in stable plaques. Ubiquitin conjugates and NF-kappaB were positively correlated with each other. It was concluded that the ubiquitin proteasome system and NF-kappaB possibly play a role in the development of atherosclerotic plaques in intracranial arteries.

机译：动脉第一段的中间脑和邻近正常血管从19个病人标本收集死于脑梗死。形态学检查的动脉粥样硬化斑块或礼物是归类为稳定不稳定的。和核因子k B (NF-kappaB)评估,发现显著更高在不稳定斑块比正常组织和更高斑比稳定的斑块。积极配合和NF-kappaB彼此相关。泛素蛋白酶体系统和NF-kappaB可能的发展发挥作用在颅内动脉粥样硬化斑块。

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《Journal of Cellular Physiology》 |2012年第2期|784-788|共5页
作者
Sun R; Xiao L; Duan S;
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作者单位

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Senile Plaques; Plaques; Cerebral InfarctionUbiquitinsUnstableConjugatesatherosclerotic plaqueNF-kappa BArteries;

机译：老年斑;斑块;脑InfarctionUbiquiti;

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High expression of ubiquitin conjugates and NF-kappaB in unstable human intracranial atherosclerotic plaques.

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