The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence.

Helmbold H; Galderisi U; Bohn W

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The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence.

机译：从复审委员会/施敏原著工程师/ p130在DNA损伤和细胞衰老。

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Cellular senescence is a response to genotoxic stress that results in an irreversible cell cycle arrest. Activation of this pathway relies on the activity of the retinoblastoma proteins and proteins of the DNA damage response cascade. Here, we discuss the functional relevance of the switch from pRb/p105 to Rb2/p130 that becomes apparent when cells enter senescent arrest.

机译：细胞衰老是一个响应基因毒性压力,结果在一个不可逆的细胞周期逮捕。视网膜母细胞瘤蛋白和活动蛋白质的DNA损伤级联反应。在这里,我们讨论的功能相关性开关从复审委员会/工程师/ p130变得施敏原著显然当细胞进入衰老被捕。

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来源
《Journal of Cellular Physiology》 |2012年第2期|508-513|共6页
作者
Helmbold H; Galderisi U; Bohn W;
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作者单位

Department of Tumorvirology, Heinrich-Pette-Institute, Leibniz-Institute for Experimental Virology, Hamburg, Germany.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
DNA Damage; Retinoblastoma; SwitchesRetinoblastoma ProteinCell Cycle CheckpointsGenotoxic StressPathwayCell AgingDNA damage response;

机译：DNA损伤;视网膜母细胞瘤;SwitchesRetinoblastomaProteinCell周期CheckpointsGenotoxicStressPathwayCell AgingDNA损伤反应;

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2. Role of Retinoblastoma Protein Family (Rb/p105 and Rb2/p130) Expression in the Histopathological Classification of Borderline Ovarian Tumors [J] . Valeria Masciullo, Gian Franco Zannoni, Paola Valdivieso, Frontiers in Medicine . 2020,第a期

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5. Mechanisms of retinoid mediated growth inhibition in ovarian carcinoma: The cell cycle proteins Rb2/p130 andp27/Kip1. [D] . Vuocolo, Scott C. 2004

机译：类维生素A介导的卵巢癌生长抑制机制：细胞周期蛋白Rb2 / p130和p27 / Kip1。
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The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence.

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