Emerging strategies for the early detection and prevention of head and neck squamous cell cancer.

Dasgupta S; Dash R; Das SKSarkar DFisher PB

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Emerging strategies for the early detection and prevention of head and neck squamous cell cancer.

机译：早期发现和新兴策略预防头颈部鳞状细胞癌。

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Despite significant improvements in therapeutic protocols, head and neck squamous cell carcinoma (HNSCC) remains a major health problem worldwide. The 5-year post-therapeutic survival rate is among the lowest of the major cancers with loco-regional relapse being the main cause of death. Moreover, in most instances, the quality of life of the afflicted patient is severely compromised. The poor prognosis for HNSCC is primarily due to disease detection at advanced stages. Accordingly, development of early detection and preventive strategies are essential. Recent advances in our understanding of the molecular biology and etiology of HNSCC should facilitate development of improved intervention and therapeutic approaches. The present review discusses the potential role of such factors for developing preventive and early diagnostic strategies for HNSCC management.

机译：尽管在治疗显著改善协议、头颈部鳞状细胞癌(HNSCC)仍然是全世界一个主要卫生问题。5年post-therapeutic存活率最低的主要癌症局部复发的主要原因死亡。生活的折磨的患者严重妥协。主要是由于在先进的疾病检测阶段。检测和预防策略必不可少的。的分子生物学和HNSCC病因应该促进发展的改善干预和治疗方法。现在回顾讨论的潜在作用这些因素对发展中预防和早期诊断为HNSCC管理策略。

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来源
《Journal of Cellular Physiology》 |2012年第2期|467-473|共7页
作者
Dasgupta S; Dash R; Das SKSarkar DFisher PB;
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作者单位

Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Disease diagnosis; poor prognosis; Head and NeckEarly DiagnosisSquamous Cell Carcinomamolecular biologyCause of Death;

机译：疾病诊断,预后不良,头NeckEarly DiagnosisSquamous细胞Carcinomamolecular biologyCause死亡;

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机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
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Emerging strategies for the early detection and prevention of head and neck squamous cell cancer.

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