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首页> 外文期刊>Journal of Cellular Physiology >PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients
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PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients

机译：PML作为一个潜在的预测因子铂/ fluoropyrimidine-based第一行在结直肠癌化疗疗效病人

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摘要

PML regulates a wide range of pathways involved in tumorigenesis, such as apoptosis, which is also one of the main mechanisms through which oxaliplatin and fluoropyrimidine exert their antineoplastic activity. The present study aims to investigate PML expression as a predictive factor of oxaliplatin/fluoropyrimidine therapy efficacy. Seventy-four metastatic colorectal cancer patients who received oxaliplatin/floropyrimidine-based first line therapy have been included in this retrospective study. PML expression was assessed by immunohistochemistry. PML down-regulation was detected in 39 (52.7%) patients (14 complete and 25 partial PML loss). RR was significantly lower (25.6%) in patients with PML down-regulation than in patients with preserved PML expression (60%) (P=0.006). Median TTP was 5.5 months when PML was down-regulated versus 11.9 months in case of preserved PML expression (P<0.0001). A statistical significant difference was also detected in OS (15.6 and 24.5 months, respectively, P=0.003). The impact of PML down-regulation on TTP and OS was statistically significant also in a multivariate model. This study represents the first evidence of a possible correlation between PML protein expression and outcome of metastatic colorectal cancer patients treated with oxaliplatin/fluoropyrimidine-based first line therapy.
机译：PML调节多种途径参与肿瘤发生,如细胞凋亡,这也是的主要机制之一铂和fluoropyrimidine发挥他们抗肿瘤的活性。研究PML表达式作为一个预测铂/倍fluoropyrimidine疗法功效。癌症病人铂/ floropyrimidine-based第一行治疗已经包含在这回顾研究。免疫组织化学。39例(52.7%)病人中发现(14和完成25部分PML损失)。(25.6%)患者的PML下调患者保存PML表达(60%)(P = 0.006)。的衰减和11.9个月保存PML表达(P < 0.0001)。统计显著差异也检测到操作系统(15.6和24.5个月,分别P = 0.003)。下调TTP和操作系统统计重要的还在多变量模型。研究代表了可能的第一个证据PML蛋白表达之间的相关性转移性结直肠癌患者的结果铂/ fluoropyrimidine-based对待第一线治疗。

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