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首页> 外文期刊>Journal of Cellular Physiology >Blood derived stem cells: An ameliorative therapy in veterinary ophthalmology
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Blood derived stem cells: An ameliorative therapy in veterinary ophthalmology

机译：血液衍生干细胞:改善治疗在兽医眼科

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摘要

Stem cell technology has evoked considerable excitement among people interested in the welfare of animals, as it has suggested the potential availability of new tools for several pathologies, including eye disease, which in many cases is considered incurable. One such example is ulcerative keratitis, which is very frequent in horses. Because some of these corneal ulcers can be very severe, progress rapidly and, therefore, can be a possible cause of vision loss, it is important to diagnose them at an early stage and administer an appropriate treatment, which can be medical, surgical, or a combination of both. The therapeutic strategy should eradicate the infection in order to reduce or stop destruction of the cornea. In addition, it should support the corneal structures and control the uveal reaction, and the pain associated with it, in order to minimize scarring. In this study, we address how stem cells derived from peripheral blood can be used also in ophthalmological pathologies. Our results demonstrate that this treatment protocol improved eye disease in four horse cases, including corneal ulcers and one case of retinal detachment. In all cases, we detected a decrease in the intense inflammatory reaction as well as the restoration of the epithelial surface of the central cornea.
机译：干细胞技术引起了相当大的兴奋感兴趣的人的福利的动物,因为它表明潜力几个可用的新工具在许多病理,包括眼科疾病情况下被认为是无法治愈的。溃疡性角膜炎,很频繁吗在马。可能非常严重,进展迅速,因此,可以设想的一个可能的原因损失,诊断是很重要的一个早期阶段和管理一个适当的治疗,医疗、外科手术或两者的结合。应该根除感染以减少或停止破坏角膜。它应该角膜的结构和支持控制葡萄膜反应,和痛苦与它相关联的,以最小化疤痕。可以使用细胞来源于外周血在眼科疾病。表明这种治疗协议改进眼疾在四匹马的情况下,包括角膜溃疡和视网膜的一个案例超然。在强烈的炎症反应的上皮表面的修复中央角膜。

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