Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation

SutherlandJ.M.; KeightleyR.A.; NixonB.RomanS.D.RobkerR.L.RussellD.L.MclaughlinE.A.

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Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation

机译：抑制细胞因子信号4 (SOCS4):主持人的卵巢原始卵泡激活

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Mammalian ovarian primordial follicle activation and regulation is considered as one of the most important stages of folliculogenesis and as such requires exquisite control. Selection of quiescent follicles to enter the growing pool determines the rate of supply of maturing follicles over the female reproductive lifespan. To coordinate this process a range of positive and negative input signals contribute to determine follicle fate. This study demonstrates that the cytokine Leukemia Inhibitory Factor (LIF) activates the Janus Kinase 1/Signal Transducers and Activators of Transcription 3 (JAK1/STAT3) signaling pathway in pre-granulosa cells and positively regulates primordial follicle activation. Negative regulation of the JAK/STAT pathway is controlled by the suppressor of cytokine signaling 4 (SOCS4) protein, which target members of negative feedback loops, Cardiotrophin like Cytokine (CLC), Poly (rC) Binding Protein 1 (PCBP1), and Cytosolic Malate Dehydrogenase (MDH1) to suppress follicle growth and development.

机译：哺乳动物卵巢原始卵泡活化和管理被认为是一种最folliculogenesis和重要阶段需要精湛的控制。静毛囊进入游泳池决定了成熟的供应速度卵泡在女性生殖寿命。这个过程协调一系列积极的和负输入信号做出贡献确定卵泡的命运。细胞因子的白血病抑制因子(生活)激活Janus激酶1 /信号传感器和转录的活化剂3在pre-granulosa JAK1 / STAT3信号通路细胞和积极调节原始毛囊激活。JAK / STAT通路的抑制控制细胞因子信号4 (SOCS4)蛋白质的目标成员的负面反馈循环,Cardiotrophin如细胞因子(CLC),聚(rC)结合蛋白1 (PCBP1)和胞质苹果酸脱氢酶(MDH1)抑制卵泡的生长和发展。

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来源
《Journal of Cellular Physiology》 |2012年第3期|1188-1198|共11页
作者
SutherlandJ.M.; KeightleyR.A.; NixonB.RomanS.D.RobkerR.L.RussellD.L.MclaughlinE.A.;
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作者单位

School of Pediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide;

Priority Research Centre in Reproductive Science Discipline of Biological Sciences, School of;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Activators; Follicles; follicular developmentCytokinesSuppressor of Cytokine Signaling ProteinsmoderatorsPrimordial Follicle;

机译：活化剂;卵泡,卵泡developmentCytokinesSuppressor的细胞因子信号ProteinsmoderatorsPrimordial卵泡;

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Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation

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