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首页> 外文期刊>Journal of Cellular Physiology >Role of insulin-like growth factors (IGFs), their receptors and genetic regulation in the chondrogenesis and growth of the mandibular condylar cartilage
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Role of insulin-like growth factors (IGFs), their receptors and genetic regulation in the chondrogenesis and growth of the mandibular condylar cartilage

机译：胰岛素样生长因子(igf)的作用,他们的受体和基因调控下颌的软骨形成和增长髁突软骨

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Growth of the mandibular condylar cartilage (MCC) is reviewed as a function of genetic and epigenetic factors. The growth centers around the differential spatial concentration of the chondrocytes, influence of growth factors like TGF-β and heterogeneity in the number of IGF receptors, control the action of IGF. Besides these factors, growth of the mandibular condyle is influenced by differential response of chondrocytes as a function of their source/ageing, which in turn is regulated by TGF-β, BMPs and IGFs. While IGF-1 promotes proteoglycan synthesis and survival of the chondrocytes to maintain cartilage homeostasis, TGF-β synergistically catalysed the effect of IGF-1, while BMPs catalysed proteolysis as and when physiologically needed. To understand these processes, role of IGF-1 and its six receptors is at the center to a number of physiological processes being regulated by its mode of application for the growth and differentiation. Probing deeper, biological functions of IGFs seemed to depend on their level of free status rather than bound status to respective IGF-binding proteins (IGF-BPs), considered prerequisite to modulate their biological functions. Genetic regulation of their secretion has thrown light on their insulin-like structural homology, level and response in osteo-arthritis (OA), rheumatic arthritis (RA) and diabetes type-II. Biochemistry and spatial distribution of IGF receptors in different domains exerts control on IGF-1 activities. In ultimate analysis, IGF-axis conserved during the evolution to regulate cell growth and proliferation affect nearly every organ in the body as judged from the techniques determining skeletal maturity and decision making dependent on it for orthodontic, orthognathic/orthopedic and dental implant applications.
机译：下颌髁突软骨(MCC)的增长综述了遗传和的函数表观遗传因素。微分的空间浓度软骨细胞,生长因子的影响TGF -β和异质性IGF的数量受体,控制IGF的作用。这些因素,下颌髁的增长由微分响应影响的软骨细胞作为他们的函数源/老化,进而是受TGF -β,bmp和igf。蛋白合成和生存的软骨细胞维持软骨内稳态,TGF -β协同催化的影响igf - 1,而我国催化蛋白质水解,当生理需要。过程中,igf - 1及其6受体的作用在许多生理中心流程被其监管模式申请生长和分化。探索更深,igf的生物功能似乎取决于他们的自由状态而不是各自的绑定状态IGF-binding蛋白质(IGF-BPs)考虑先决条件调节他们的生物功能。丢光了他们的胰岛素样结构同源性,osteo-arthritis水平和反应(OA)、风湿性关节炎(RA)和糖尿病二型。IGF受体在不同领域施加控制igf - 1的活动。在进化IGF-axis守恒调节细胞生长和增殖的影响几乎每一个器官在体内的判断技术确定骨骼成熟度和决策依赖于矫正,orthognathic /骨科和牙科植体应用程序。

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