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首页> 外文期刊>Journal of Cellular Physiology >Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF-kappaB (RANK).
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Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF-kappaB (RANK).

机译：骨吸收牙爆发和根的控制形态发生:受体的参与活化剂的NF-kappaB(等级)。

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摘要

Activation of the receptor activator of NF-kappaB (RANK) is a crucial step in osteoclastogenesis. Loss- and gain-of-function mutations in the Rank gene cause, respectively, osteopetrosis and several forms of extensive osteolysis. Tooth and alveolar bone alterations are associated with these pathologies but remain to be better characterized. The aim of the present study was to establish the tooth and alveolar bone phenotype of a transgenic mouse model of RANK over-expression in osteoclast precursors. Early tooth eruption and accelerated tooth root elongation were observed subsequent to an increase in osteoclast numbers surrounding the tooth. The final root length appeared not to be affected by RANK over-expression, but a significant reduction in root diameter occurred in both control and root-morphogenesis-defective Msx2 null mutant mice. These results indicate that root length is independent of the surrounding bone resorption activity. In contrast, root diameter is sensitive to the activity of alveolar bone osteoclasts. These data suggest that early eruption and thin root are phenotypic features that could be associated with extensive osteolytic pathologies.
机译：激活NF-kappaB受体激活的osteoclastogenesis(等级)是一个至关重要的一步。损失和功能的突变分别基因导致骨硬化病几种形式的广泛的骨质溶解。牙槽骨的改变有关这些病态,但仍有待更好为特征。建立牙和牙槽骨表型的转基因小鼠模型在破骨细胞前体表达。牙齿喷发和加速牙根伸长观察后续的周围的破骨细胞数量的增加牙齿。排名影响表达,但是根直径显著减少发生在这两个控制和root-morphogenesis-defectiveMsx2零突变小鼠。根的长度无关周围的骨吸收活动。相反,根直径是敏感的牙槽骨破骨细胞的活性。表明,早期喷发和细根表型特征联系在一起广泛的溶骨的病态。

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