New players in ovarian cancer.

Bovicelli A; DAndrilli G; Giordano A

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New players in ovarian cancer.

机译：卵巢癌的新球员。

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摘要

Ovarian cancer is the leading cause of gynecologic cancer mortality worldwide. The aim of this review is to highlight the most recent studies regarding ovarian cancer pathogenesis and the new therapeutic approaches against this insidious disease. We focus on the relevance of some cell cycle genes, transcription factors, and microRNAs in the carcinogenesis of ovarian cancer as well as on a new hypothesis for therapy using histone deacetylase inhibitors. We also report recent studies regarding some mechanisms of chemoresistance, a major obstacle in the treatment of ovarian cancer. Together these studies can improve our knowledge of ovarian cancer tumorigenesis and diagnosis providing new tools to hopefully defeat this deadly disease.

机译：卵巢癌是妇科的主要原因全球癌症死亡率。是强调最近的研究关于卵巢癌发病机制和新治疗方法对这种阴险疾病。周期基因、转录因子、小分子核糖核酸卵巢癌的致癌作用使用组蛋白作为治疗的新假说脱乙酰酶抑制剂。研究关于一些机制化学抗性的一个主要障碍卵巢癌的治疗。卵巢癌的研究可以提高我们的知识癌症肿瘤发生和诊断提供新的工具希望击败这种致命的疾病。

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来源
《Journal of Cellular Physiology》 |2011年第10期|2500-2504|共5页
作者
Bovicelli A; DAndrilli G; Giordano A;
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作者单位

Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Players; Ovary Cancer; Histone Deacetylase InhibitorsMicroRNAsCarcinogenesis;

机译：球员;卵巢肿瘤;组蛋白脱乙酰酶;

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New players in ovarian cancer.

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