RARgamma is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.

Amat R; Gudas LJ

首页> 外文期刊>Journal of Cellular Physiology >RARgamma is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.

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RARgamma is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.

机译：RARgamma需要正确的沉积和删除Suz12 H2A。细胞。

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Retinoic acid (RA) induces embryonic stem cell differentiation. The effects of RA are mediated by retinoic acid receptors (RARs) that promote epigenetic changes controlling gene transcription. We show here that RARgamma, in the absence of the ligand RA, is required for deposition of the histone variant H2A.Z and the polycomb group protein Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand. Addition of RA causes removal of H2A.Z and Suz12 from RARgamma target genes when the genes are transcriptionally activated.

机译：维甲酸(RA)诱导胚胎干细胞分化。视黄酸受体(rar)促进表观遗传变化控制基因转录。没有配体RA,是必需的H2A沉积的组蛋白变体。polycomb组蛋白在RA Suz12目标基因,在胚胎干细胞RARgamma和Suz12存在于一个复杂的多没有配体。H2A。当基因转录激活。

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《Journal of Cellular Physiology》 |2011年第2期|293-298|共6页
作者
Amat R; Gudas LJ;
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Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA.;

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正文语种英语
中图分类细胞生物学;
关键词
histone H2AZ; Embryonic Stem Cells; Epigenetic ChangeGenetic TranscriptionStem Cells;

机译：组蛋白H2AZ;胚胎干细胞;表观遗传ChangeGenetic TranscriptionStem细胞;

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1. Mechanisms underlying the self-renewal characteristic and cardiac differentiation of mouse embryonic stem cells. [O] . 2009

机译：mechanisms underlying the self-renewal characteristic and cardiac differentiation of mouse embryonic stem cells.

RARgamma is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.

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