...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >The Hippo pathway in biological control and cancer development.
【24h】

The Hippo pathway in biological control and cancer development.

机译：河马通路的生物防治和癌症发展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Hippo pathway is an evolutionally conserved protein kinase cascade involved in regulating organ size in vivo and cell contact inhibition in vitro by governing cell proliferation and apoptosis. Deregulation of the Hippo pathway is linked to cancer development. Its first core kinase Warts was identified in Drosophila more than 15 years ago, but it gained much attention when other core components of the pathway were identified 8 years later. Major discoveries of the pathway were made during past several years. The core kinase components Hippo, Salvador, Warts, and Mats in the fly and Mst1/2, WW45, Lats1/2, and Mob1 in mammals phosphorylate and inactivate downstream transcriptional co-activators Yorkie in the fly, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in mammals, respectively. Phosphorylated Yorkie, YAP, and TAZ are sequestered in the cytoplasm by interaction with 14-3-3 proteins. Here we review recent progresses of this pathway by focusing on how these proteins communicate with each other and how loss of regulation results in cancers.
机译：散播他们的河马通路是守恒的参与调节蛋白激酶级联体内器官的大小和细胞接触抑制通过调节细胞增殖和体外细胞凋亡。与癌症的发展。激酶疣在果蝇中被确定比15年前,但它得到了太多的关注当其他途径的核心组件确定了8年。在过去的几年里的途径。核心激酶组件河马、萨尔瓦多疣,垫在飞和Mst1/2 WW45,在哺乳动物使磷酸化和Lats1/2, Mob1灭活下游转录co-activators约克夏的飞,Yes-associated蛋白质(笨蛋)和转录co-activatorPDZ-binding主题(小胡子)在哺乳动物中,分别。隐藏在细胞质的互动14-3-3蛋白。通过专注于如何发展的途径这些蛋白质相互通信如何监管导致癌症的损失。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号