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首页> 外文期刊>Journal of Cellular Physiology >Dicer is required for the formation of white but not brown adipose tissue.
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Dicer is required for the formation of white but not brown adipose tissue.

机译：帽子是白色的形成,但所需褐色脂肪组织。

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Dicer, an enzyme involved in microRNA maturation, is required for proper embryo gastrulation and tissue morphogenesis during mammalian development. Using primary cultures of fibroblasts and pre-adipocytes, we have previously shown that Dicer is essential for early stages of adipogenic cell differentiation. In this study, we have utilized Dicer-conditional mice to explore a role for Dicer and microRNA biogenesis in the terminal differentiation of adipocytes in vivo and in the formation of white and brown adipose tissue. Deletion of Dicer in differentiated adipocytes in Dicer-conditional, aP2-Cre transgenic mice reduced the level of various adipogenic-associated transcripts and inhibited lipogenesis in white adipocytes, resulting in a severe depletion of white adipose tissue in mice. In contrast, Dicer was not required in vivo for lipogenesis in brown adipose or for brown fat formation. However, Dicer deletion in brown adipose did decrease the expression of genes involved in thermoregulation. The results of our study provide genetic evidence of a role for microRNA molecules in regulating adipogenesis and reveal distinct requirements for Dicer in the formation of white and brown adipose tissue.
机译：小礼帽,一种酶参与microRNA成熟,需要适当的胚胎原肠胚形成和在哺乳动物组织形态发生发展。成纤维细胞和pre-adipocytes,先前表明,帽子是必不可少的脂肪形成的细胞分化的早期阶段。在这项研究中,我们利用Dicer-conditional老鼠探索帽子和微rna的作用生物起源的终端分化脂肪细胞在体内和白色的形成和棕色脂肪组织。在Dicer-conditional分化脂肪细胞,aP2-Cre转基因老鼠的水平降低各种adipogenic-associated成绩单和在白色脂肪细胞,抑制脂肪生成导致严重的白色脂肪消耗组织在老鼠身上。需要体内褐色脂肪的脂肪生成或者棕色脂肪的形成。删除在褐色脂肪减少在温度调节相关基因的表达。我们的研究结果提供遗传学证据microRNA分子调节的作用脂肪生成和显示不同的要求帽子在白色和褐色脂肪的形成组织。

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