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首页> 外文期刊>Journal of Cellular Physiology >Nupr1: the Swiss-knife of cancer.
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Nupr1: the Swiss-knife of cancer.

机译：Nupr1:癌症的瑞士军刀。

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摘要

Nupr1 is a small, highly basic and loosely folded multifunctional protein whose expression is induced by several stresses. Its relation to cancer was first suggested by its overexpression in several human malignancies and the association of its expression with breast cancer metastasis. Accordingly, Nupr1 is structurally related to the high-mobility group (HMG) of transcriptional regulators, which play a key role in the stress response and in cancer progression. Nupr1 interacts with numerous partners to regulate cell cycle, programmed cell death, autophagy, chromatin accessibility, and transcription, and its expression is required for regulation of TGFbeta activity. Pleiotropic functions accomplished by Nupr1 depend on its molecular partners, its location into the cell, its expression level and on the cell-type. Nupr1 might be a new drug-targetable protein whose blockade would prevent cancer progression and metastasis development.
机译：Nupr1是一个小的、高度基本和松散折叠多功能蛋白的表达引起一些压力。癌症是首先提出了其超表达在一些人类恶性肿瘤和协会的表达与乳腺癌转移。因此,Nupr1结构有关高机动组(邮政编码)的转录监管机构,发挥关键作用的压力反应和癌症进展。与众多合作伙伴来调节细胞周期,程序性细胞死亡,自噬,转录和染色质易访问性其表达式的监管需要TGFbeta活动。通过Nupr1取决于其分子来实现的合作伙伴,其位置进入细胞,表达水平和程控。可能是一个新的drug-targetable蛋白质的可以防止癌症进展和封锁转移的发展。

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