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首页> 外文期刊>Journal of Cellular Physiology >FEZ1/LZTS1 protein expression in ovarian cancer.
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FEZ1/LZTS1 protein expression in ovarian cancer.

机译：在卵巢癌FEZ1 / LZTS1蛋白表达。

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The FEZ1/LZTS1 (FEZ1) gene maps to chromosome 8p22 and is frequently altered in human cancer. FEZ1 has been proposed as a candidate tumour suppressor gene and its loss may contribute to tumour progression. We have analysed the expression of FEZ1 protein in tissues from ovarian carcinomas in relation to clinico-pathological variables, response to chemotherapy and disease-free and overall survival. FEZ1 status was assessed by immunohistochemistry. Cytoplasmic staining for FEZ1 protein was absent or drastically reduced in 38% of tumours. FEZ1 protein expression was not related to tumour grade, histotype, disease-free survival, or overall survival. On the contrary, it was significantly correlated with age and with FIGO stage of disease. This finding indicates that FEZ1 is involved in ovarian carcinogenesis. Moreover, loss of FEZ1 protein significantly predicted a complete treatment response in patients who received taxane-based chemotherapy. In conclusion, the reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma.
机译：FEZ1 / LZTS1 (FEZ1)基因地图染色体8第22位在人类癌症和经常改变。提出了作为候选肿瘤抑制基因及其可能导致的损失肿瘤进展。表达FEZ1蛋白质在组织卵巢癌有关二变量,回应化疗和无病和整体生存。免疫组织化学。FEZ1蛋白质缺失或大幅减少肿瘤的38%。与肿瘤相关的年级,histotype,无病生存,或总体存活率。它是随着年龄的增长而显著相关菲戈阶段的疾病。FEZ1参与卵巢致癌作用。此外,FEZ1蛋白显著的损失预测一个完整的治疗反应病人taxane-based化疗。总之,FEZ1的减少或损失蛋白质可以帮助临床管理的病人受卵巢的影响癌。

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