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首页> 外文期刊>Journal of Cellular Physiology >Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.
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Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.

机译：在epithelial-mesenchymal Zyxin控制迁移过渡的中介actin-membrane联系在信息方面找到了契合点。

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摘要

Development is punctuated by morphogenetic rearrangements of epithelial tissues, including detachment of motile cells during epithelial-mesenchymal transition (EMT). Dramatic actin rearrangements occur as cell-cell junctions are dismantled and cells become independently motile during EMT. Characterizing dynamic actin rearrangements and identifying actin machinery driving these rearrangements is essential for understanding basic mechanisms of cell-cell junction remodeling. Using immunofluorescence and live cell imaging of scattering MDCK cells we examine dynamic actin rearrangement events during EMT and demonstrate that zyxin-VASP complexes mediate linkage of dynamic medial actin networks to adherens junction (AJ) membranes. A functional analysis of zyxin in EMT reveals its role in regulating disruption of actin membrane linkages at cell-cell junctions, altering cells' ability to fully detach and migrate independently during EMT. Expression of a constitutively active zyxin mutant results in persistent actin-membrane linkages and cell migration without loss of cell-cell adhesion. We propose zyxin functions in morphogenetic rearrangements, maintaining collective migration by transducing individual cells' movements through AJs, thus preventing the dissociation of individual migratory cells.
机译：发展形态形成所打断上皮组织的重组,包括超然的能动的细胞中epithelial-mesenchymal过渡(EMT)。肌动蛋白重组发生的信息连接拆除,细胞成为独立在EMT能动的。重组和识别肌动蛋白机械推动这些重组是至关重要的理解信息的基本机制结重构。我们活细胞成像的散射MDCK细胞在分析动态肌动蛋白重组事件EMT和证明zyxin-VASP复合物调节连杆的动态内侧肌动蛋白网络adherens结(AJ)膜。zyxin EMT揭示其作用的分析调节肌动蛋白膜中断联系在信息连接,改变细胞的能力完全分离和独立迁移EMT。在持久actin-membrane突变的结果没有失去联系和细胞迁移信息附着力。形态形成重组、维护个人集体迁移转换细胞的运动通过五角,从而阻止了分离的个体细胞迁徙。

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