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首页> 外文期刊>Journal of Cellular Physiology >Heat shock but not cold shock leads to disturbed intracellular zinc homeostasis.
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Heat shock but not cold shock leads to disturbed intracellular zinc homeostasis.

机译：热休克而不是冷休克导致干扰细胞内锌体内平衡。

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摘要

The heat shock response is a highly conserved process essential for surviving environmental stress, including extremes of temperature. To investigate whether heat shock has an impact on intracellular Zn(2+) homeostasis, cells were subjected to heat shock, and subsequently the intracellular free zinc concentration was investigated. Sublethal heat shock induced a temperature-dependent and transient intracellular Zn(2+) release that was repeatable after 24 h. The free zinc was localized in round-shaped nuclear bodies identified as nucleoli. Metallothionein, the main cellular zinc storing protein, was found to be not functionally essential for this heat-shock-induced effect. No significant oxidative stress within the cells was detected after heat shock. Cold shock and subsequent rewarming did not result in disturbed intracellular zinc homeostasis. These results show that heat shock and cold shock differ with respect to intracellular Zn(2+) release. A role for zinc as signaling ion during fever is conceivable.
机译：热休克反应是一个高度保守的过程必不可少的生存环境压力,包括极端的温度。探讨热休克是否有影响(2 +)细胞内锌体内平衡,细胞受到热休克,随后细胞内游离锌浓度调查。随温度而变的和瞬态细胞内锌(2 +)释放,24小时后可重复的。免费的锌在圆形本地化核机构确认为核仁。金属硫蛋白,主要细胞锌储存蛋白质,不被发现的功能这种heat-shock-induced效应的必要条件。重要的细胞内氧化应激热休克后发现。随后复温不产生干扰细胞内锌体内平衡。表明热休克和冷休克不同对细胞内锌(2 +)释放。锌离子的信号在发烧可以想象。

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