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首页> 外文期刊>Journal of Cellular Physiology >Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes.
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Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes.

机译：肌原性的骨骼肌卫星细胞通过隧道纳米管沟通。

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摘要

Quiescent satellite cells sit on the surface of the muscle fibres under the basal lamina and are activated by a variety of stimuli to disengage, divide and differentiate into myoblasts that can regenerate or repair muscle fibres. Satellite cells adopt their parent's fibre type and must have some means of communication with the parent fibre. The mechanisms behind this communication are not known. We show here that satellite cells form dynamic connections with muscle fibres and other satellite cells by F-actin based tunnelling nanotubes (TNTs). Our results show that TNTs readily develop between satellite cells and muscle fibres. Once developed, TNTs permit transport of intracellular material, and even cellular organelles such as mitochondria between the muscle fibre and satellite cells. The onset of satellite cell differentiation markers Pax-7 and MyoD expression was slower in satellite cells cultured in the absence than in the presence of muscle cells. Furthermore physical contact between myofibre and satellite cell progeny is required to maintain subtype identity. Our data establish that TNTs constitute an integral part of myogenic cell communication and that physical cellular interaction control myogenic cell fate determination.
机译：坐在静止卫星细胞的表面基板和下的肌肉纤维被各种各样的刺激激活中解脱出来,分裂和分化成肌母细胞再生或修复肌肉纤维。细胞采用他们的父母的纤维类型和必须有一些与父母沟通的手段吗纤维。是不知道。动态连接与肌肉纤维和形式其他卫星细胞通过基于f -肌动蛋白的隧道纳米管(tnt)。卫星细胞和间迅速发展肌肉纤维。细胞内物质运输,甚至细胞的细胞器如线粒体之间肌肉纤维和卫星细胞。卫星细胞分化标记Pax-7和MyoD表达在卫星细胞慢培养在没有的存在肌肉细胞。myofibre之间和卫星细胞的后代需要保持亚型的身份。建立tnt构成不可分割的一部分肌原性的细胞通讯和物理细胞肌原性的交互控制细胞的命运的决心。

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