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首页> 外文期刊>Journal of Cellular Physiology >Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process.
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Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process.

机译：糖酵解的链接与NF-kappaB p53功能信号:对癌症和衰老过程的影响。

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In 1930, Otto Warburg observed that cancer cells produce an increased amount of their energy through aerobic glycolysis and subsequently, this was called the Warburg effect. During aging, the capacity for mitochondrial respiration clearly declines and aerobic glycolysis appears to compensate for the deficiency in oxidative metabolism. This shift in energy production, both in aging and cancer, could protect from the toxic effects of oxygen free radicals whereas increased glycolysis can have adverse effects. It was recently demonstrated that the glycolysis-linked protein O-glycosylation can potentiate the catalytic activity of IKK beta and subsequently trigger NF-kappaB signaling. It seems that tumor suppressor oncogene p53 has an important role in the regulation of protein O-glycosylation since p53 is a potent inhibitor of glycolysis, for example, via TIGAR protein expression. Aging is known to repress the function of p53 and this could enhance glycolysis and NF-kappaB signaling. We will discuss the role of p53 in the regulation of glycolysis-dependent activation of NF-kappaB signaling in both cancer and aging process.
机译：1930年,奥托华宝观察到癌细胞产生的能量增加通过有氧糖酵解,随后,这个被称为Warburg效应。线粒体呼吸的能力下降和有氧糖酵解似乎在氧化弥补不足新陈代谢。在衰老和癌症,可以防止有毒氧自由基的影响而增加糖酵解可以有不利影响。最近证明了glycolysis-linked蛋白质O-glycosylation可以加强IKK beta和随后的催化活性触发NF-kappaB信号。抑制癌基因p53有着重要的作用蛋白质O-glycosylation的规定p53是糖酵解的有效抑制剂示例中,通过TIGAR蛋白表达。已知压制p53和这个的功能可以增强糖酵解和NF-kappaB信号。我们将讨论p53在监管的作用NF-kappaB glycolysis-dependent激活信号在癌症和衰老过程。

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