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首页> 外文期刊>Journal of Cellular Physiology >Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology.
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Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology.

机译：胰岛素样生长因子之间的相互作用(IGF)轴和膜整合蛋白来调节细胞生理机能。

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摘要

The biology of cross-talk between activated growth factor receptors and cell-surface integrins is an area which has attracted much interest in recent years (Schwartz and Ginsberg, 2002). This review discusses the relationship between the insulin-like growth factor (IGF) axis and cell-surface integrin receptors in the regulation of various aspects of cell physiology. Key to these interactions are signals transmitted between integrins and the IGF-I receptor (IGF-IR) when either or both are bound to their cognate ligands and we will review the current state of knowledge in this area. The IGF axis comprises many molecular components and we will also discuss the potential role of these species in cross-talk with the integrin receptor. With respect to integrin ligands, we will mainly focus on the well-characterized interactions of the two extracellular matrix (ECM) glycoproteins fibronectin (FN) and vitronectin (VN) with cell-surface ligands, and, how this affects activity through the IGF axis. However, we will also highlight the importance of other integrin activation mechanisms and their impact on IGF activity.
机译：相声的生物学活性之间的增长因子受体和细胞表面蛋白是一个领域,吸引了很多最近的兴趣年(施瓦茨和金斯堡,2002)。讨论之间的关系胰岛素样生长因子(IGF)轴细胞表面整合素受体的监管的细胞生理学的各个方面。这些交互是信号传输整合蛋白与IGF-I受体(IGF-IR)当有一方或者双方都绑定到他们的同族配体,我们将审查的当前状态在这一领域的知识。许多分子组件,我们也会讨论这些物种的潜在作用相声的整合素受体。对整合素配体,我们将主要关注良好的交互的两个细胞外基质(ECM)糖蛋白纤连蛋白(FN)和vitronectin (VN)细胞表面配体,这如何影响通过互联网管理论坛活动轴。还强调其他整合素的重要性对IGF激活机制及其影响活动。

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