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首页> 外文期刊>Journal of Cellular Physiology >The epidermal growth factor receptor ligands at a glance.
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The epidermal growth factor receptor ligands at a glance.

机译：表皮生长因子受体配体在一个一瞥。

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摘要

The epidermal growth factor receptor (EGFR) regulates key processes of cell biology, including proliferation, survival, and differentiation during development, tissue homeostasis, and tumorigenesis. Canonical EGFR activation involves the binding of seven peptide growth factors. These ligands are synthesized as transmembrane proteins comprising an N-terminal extension, the EGF module, a short juxtamembrane stalk, a hydrophobic transmembrane domain, and a carboxy-terminal fragment. The central structural and functional feature is the EGF module, a sequence containing six cysteines in a conserved spacement which is responsible for binding to the EGFR. While the membrane-anchored peptide can be biologically active by juxtacrine signaling, in most cases the EGF module is proteolytically cleaved (a process termed ectodomain shedding) to release the soluble growth factor, which may act in an endocrine, paracrine, or autocrine fashion. This review summarizes the structural and functional properties of these fascinating molecules and presents selected examples to illustrate their roles in development, physiology, and pathology.
机译：表皮生长因子受体(EGFR)调节细胞生物学的关键过程,包括增殖、生存,和在开发过程中分化,组织体内平衡和肿瘤发生。激活涉及七肽的绑定生长因子。跨膜蛋白组成的氨基端扩展,EGF模块,短近膜茎,疏水跨膜域和carboxy-terminal片段。是EGF模块和功能特性,序列包含六个半胱氨酸在守恒的spacement负责绑定的表皮生长因子受体。juxtacrine信号、生物活性大多数情况下,proteolytically EGF模块裂解(这一过程称为ectodomain脱落)溶性生长因子释放,可能会采取行动在内分泌、旁分泌或自分泌的方式。本文总结了结构和这些迷人的功能性质分子和礼物选择的例子说明他们的角色在发展,生理和病理。

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