Tumor liberated protein from lung cancer and perspectives for immunotherapy.

Tarro G

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Tumor liberated protein from lung cancer and perspectives for immunotherapy.

机译：从肺癌和肿瘤蛋白质中解放出来免疫治疗的观点。

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This review addresses peptide regions of human tumor liberated protein (TLP) complexes with antigenic activity. The review also deals with antibodies reacting with such proteins, to be used for diagnostic and clinical purposes. We identified peptide sequences of the TLP 100 kDa protein. Lung cancer cells were found positive with an immuno-histochemical test, by peroxidase-anti-peroxidase, using a specific antiserum. This test turned out negative in the presence of the synthesized peptide (blocking test). Several tumors were used to obtain antigens by various purification procedures (cell homogenization, ultracentrifugation at 100,000g, gel filtration and chromatography, preparative and analytical isoelectric focusing, IEF). The molecular weight on SDS-PAGE of an immunogenic peak detected on IEF was determined to be a value of 214,000 Da, with monomers of 54,000 Da. In vivo TLP yields delayed hypersensitivity reactions in both autologous and homologous hosts, and does not seem to have any nonspecific mytogenic activity, but does have mytogenic-specific activity since lymphocyte blastogenesis (TLP-induced in pre-sensitized patients), in the case of intradermal inoculation, could mean its ability to sensitize a lymphocytic clone.

机译：本文地址肽区域的人类肿瘤解放蛋白质(TLP)复合物抗原的活动。与这些蛋白质,抗体反应用于诊断和临床用途。发现的肽序列TLP 100 kDa蛋白质。immuno-histochemical测试,peroxidase-anti-peroxidase,使用一个特定的抗血清。的合成肽(阻塞测试)。(细胞抗原由不同的净化过程均质化,超速离心法在100000克,凝胶过滤色谱法,制备和分析等电点聚焦,)。分子量在sds - page的免疫原性峰值检测能源论坛上合作,确定一个值214000 Da, 54000 Da的单体。体内TLP收益率延迟超敏反应反应和自体同源主机,似乎并没有任何非特异性mytogenic活动,但也有mytogenic-specific活动以来的淋巴细胞胚芽生殖(TLP-induced pre-sensitized病人),在皮内注射的情况下接种,可能意味着其进行宣传的能力淋巴细胞克隆。

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《Journal of Cellular Physiology》 |2009年第1期|26-30|共5页
作者
Tarro G;
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作者单位

Department of Biology, Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Lymphocyte Activation; Molecular weights; Delayed HypersensitivityLung CancerimmunotherapyPerspectiveProteinSDS-PAGEautologous bone marrow transplantsPeptidesTumours;

机译：淋巴细胞活化,分子量;延迟HypersensitivityLung;

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Tumor liberated protein from lung cancer and perspectives for immunotherapy.

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