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首页> 外文期刊>Journal of Cellular Physiology >A probabilistic model for the arrangement of a subset of human chromosome territories in WI38 human fibroblasts.
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A probabilistic model for the arrangement of a subset of human chromosome territories in WI38 human fibroblasts.

机译：概率模型的安排人类染色体在WI38领土的子集人类成纤维细胞。

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摘要

There is growing evidence that chromosome territories have a probabilistic non-random arrangement within the cell nucleus of mammalian cells. Other than their radial positioning, however, our knowledge of the degree and specificity of chromosome territory associations is predominantly limited to studies of pair-wise associations. In this study we have investigated the association profiles of eight human chromosome pairs (numbers 1, 2, 3, 4, 6, 7, 8, 9) in the cell nuclei of G(0)-arrested WI38 diploid lung fibroblasts. Associations between heterologous chromosome combinations ranged from 52% to 78% while the homologous chromosome pairs had much lower levels of association (3-25%). A geometric computational method termed the Generalized Median Graph enabled identification of the most probable arrangement of these eight chromosome pairs. Approximately 41% of the predicted associations are present in any given nucleus. The association levels of several chromosome pairs were very similar in a series of lung fibroblast cell lines but strikingly different in skin and colon derived fibroblast cells. We conclude that a large subset of human chromosomes has a preferred probabilistic arrangement in WI38 cells and that the resulting chromosomal associations show tissue origin specificity.
机译：越来越多的证据表明,染色体地区有一个概率随机安排在哺乳动物的细胞核细胞。然而,我们的知识程度特异性染色体领土的关联主要是限于研究双向吗关联。协会的八人染色体配对(数字1、2、3、4、6,7,8,9)细胞核的G(0)逮捕WI38二倍体肺成纤维细胞。从不同的染色体组合52%到78%的同源染色体配对水平低得多的协会(3 - 25%)。几何计算方法称为广义中值图像识别启用这八个最可能的安排染色体配对。出现在任何给定的预测关联原子核。在一系列的染色体配对非常相似肺成纤维细胞细胞系但惊人不同的皮肤和结肠派生的纤维母细胞细胞。染色体有一个首选的概率安排在WI38细胞产生的染色体协会组织起源特异性。

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