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首页> 外文期刊>Journal of Cellular Physiology >Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha.
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Generation of a human immunodeficiency virus type 1 chronically infected monkey B cell line expressing low levels of endogenous TRIM5alpha.

机译：一代的人类免疫缺陷病毒类型1慢性感染猴B细胞系内生TRIM5alpha表达低水平的。

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摘要

Several innate cellular antiviral factors exist in mammalian cells that prevent the replication of retroviruses. Among them, the tripartite motif protein (TRIM)5alpha has been shown to block human immunodeficiency virus type 1 (HIV-1) infection in several types of Old World monkey cells. Here we report a novel HIV-1 chronically infected monkey B cell line, F6/HIV-1, characterized by very low levels of TRIM5alpha expression that allows HIV-1 to overcome the restriction. Virus produced by F6/HIV-1 cells fails to infect monkey cells but retains the ability to infect human peripheral blood mononuclear cells (PBMCs) and T cell lines, although with a reduced infectivity compared to the input virus. Ultrastructural analyses revealed the presence of budding virions at the F6/HIV-1 cells plasma membrane characterized by a typical conical core shell. To our knowledge F6/HIV-1 is the first monkey cell line chronically infected by HIV-1 and able to release infectious particles thus representing a useful tool to gain further insights into the molecular mechanisms of HIV-1 pathogenesis.
机译：存在一些先天细胞抗病毒因子哺乳动物细胞,防止复制逆转录病毒。蛋白(修剪)5α块人类免疫缺陷病毒1型(hiv - 1)感染的几种类型的旧世界猴细胞。感染猴B细胞系,F6 / hiv - 1,特点是TRIM5alpha水平很低表达式允许hiv - 1克服限制。未感染猴细胞但保留了感染人类外周血的能力单核细胞(PBMCs)和T细胞系,尽管相比减少传染性输入病毒。了出芽病毒粒子的存在F6 / hiv - 1细胞的质膜的特点典型的锥形芯壳。F6 / hiv - 1是第一个猴子细胞系慢性感染hiv - 1和释放感染性粒子从而代表一个有用的工具来获得进一步的洞察分子hiv - 1发病机制。

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