Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.

Hsu HY; Hua KF; Wu WCHsu JWeng STLin TLLiu CYHseu RSHuang CT

首页> 外文期刊>Journal of Cellular Physiology >Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.

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Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.

机译：灵芝immuno-modulation蛋白诱发白介素2通过蛋白质表达kinase-dependent信号通路在人类T细胞。

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摘要

Ganoderma lucidum, a medicinal fungus is thought to possess and enhance a variety of human immune functions. An immuno-modulatory protein, Ling Zhi-8 (LZ-8) isolated from G. lucidum exhibited potent mitogenic effects upon human peripheral blood lymphocytes (PBL). However, LZ-8-mediated signal transduction in the regulation of interleukin-2 (IL-2) gene expression within human T cells is largely unknown. Here we cloned the LZ-8 gene of G. lucidum, and expressed the recombinant LZ-8 protein (rLZ-8) by means of a yeast Pichia pastoris protein expression system. We found that rLZ-8 induces IL-2 gene expression via the Src-family protein tyrosine kinase (PTK), via reactive oxygen species (ROS), and differential protein kinase-dependent pathways within human primary T cells and cultured Jurkat T cells. In essence, we have established the nature of the rLZ-8-mediated signal-transduction pathways, such as PTK/protein kinase C (PKC)/ROS, PTK/PLC/PKCalpha/ERK1/2, and PTK/PLC/PKCalpha/p38 pathways in the regulation of IL-2 gene expression within human T cells. Our current results of analyzing rLZ-8-mediated signal transduction in T cells might provide a potential application for rLZ-8 as a pharmacological immune-modulating agent.

机译：灵芝,药用真菌被认为拥有和提高各种人类免疫功能。Zhi-8 (LZ-8)与g .清明的展出噪音对人类外围的促有丝分裂的影响血淋巴细胞(PBL)。信号转导的规定在人类白介素2(- 2)基因表达T细胞在很大程度上是未知的。LZ-8基因g .清明的,表达了重组LZ-8蛋白质(rLZ-8)通过毕赤酵母属酵母pastoris蛋白表达系统。我们发现rLZ-8诱发- 2基因的表达通过Src-family蛋白质酪氨酸激酶(PTK),通过活性氧(ROS),差异蛋白质kinase-dependent通路在人类原发性T细胞和培养JurkatT细胞。的本质rLZ-8-mediated信号转导途径,如强/蛋白激酶C (PKC) / ROS,强/ PLC / PKCalpha / ERK1/2,强/ PLC / PKCalpha / p38在- 2基因的调控途径人类T细胞内表达。rLZ-8-mediated信号分析的结果在T细胞转导可能提供一个潜在的申请rLZ-8药理immune-modulating代理。

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来源
《Journal of Cellular Physiology》 |2008年第1期|15-26|共12页
作者
Hsu HY; Hua KF; Wu WCHsu JWeng STLin TLLiu CYHseu RSHuang CT;
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作者单位

Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan. rshseu@ntu.edu.tw;

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正文语种英语
中图分类细胞生物学;
关键词
Signal Transduction; Gene Expression Regulation; CD3 AntigensFungal ProteinsInterleukin-2Calcium SignalingMycoproteinT-LymphocytesProteinIL2 geneReishi;

机译：信号转导、基因表达调控CD3SignalingMycoproteinT-LymphocytesProteinIL2geneReishi;

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Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.

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