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首页> 外文期刊>Journal of Cellular Physiology >Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells.
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Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells.

机译：Lipocalin 2-mediated生长抑制明显在人类红细胞和单核细胞/巨噬细胞谱系细胞。

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摘要

Lipocalin 2 (LCN2), a secreted protein of the lipocalin family, induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. We have recently reported that LCN2 inhibits the production of red blood cells in the mouse. Here we analyzed the role of LCN2 in human hematopoiesis. Expression of LCN2 was observed not only in mature cells such as those of the granulocyte/macrophage and erythroid lineages but also in hematopoietic stem/progenitor cells. We also examined expression of two candidate receptors for LCN2, brain type organic cation transporter (BOCT) and megalin, in various cell types. BOCT showed relatively high levels of expression in erythroid and hematopoietic stem/progenitor cells but lower levels in granulocyte/macrophage and T lymphoid cells. Megalin was expressed at high levels in T lymphoid and erythroid cells but at lower levels in granulocyte/macrophage lineage cells. LCN2 suppressed the growth of erythroid and monocyte/macrophage lineages in vitro, but did not have this effect on cells of other lineages. In addition, immature hematopoietic stem/progenitor cells were not sensitive to LCN2. These results demonstrate a lineage-specific role for LCN2 in human hematopoiesis that is reminiscent of its effects upon mouse hematopoiesis and strongly suggest an important in vivo function of LCN2 in the regulation of human hematopoiesis.
机译：Lipocalin 2 (LCN2)分泌的蛋白质在某些类型lipocalin家庭,诱发细胞凋亡细胞和抑制细菌生长封存iron-laden细菌含铁细胞。抑制红细胞的生产鼠标。造血作用。不仅在成熟的细胞如粒细胞/巨噬细胞和红细胞血统在造血干/祖细胞。还研究了两个候选人的表达有机阳离子受体LCN2,大脑类型转运体(BOCT)和megalin各种细胞类型。表达在红细胞和造血干细胞/祖细胞,但较低的水平粒细胞/巨噬细胞和T淋巴细胞。Megalin表达高水平的T淋巴细胞和红细胞,但在较低的水平在粒细胞/巨噬细胞系的细胞。抑制红细胞和的发展单核细胞/巨噬细胞体外血统,但所做的没有这种影响细胞的其他血统。此外,不成熟的造血干/祖细胞LCN2并不敏感。这些结果表明lineage-specific角色LCN2人类造血作用让人联想到对老鼠的影响造血作用,强烈建议一个重要体内LCN2调节的功能人类造血作用。

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