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首页> 外文期刊>Journal of Cellular Physiology >Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation.
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Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation.

机译：骨骼肌细胞表达profibrotic细胞因子结缔组织生长因子(CTGF / CCN2),导致他们的去分化。

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摘要

Fibrotic disorders are typified by excessive connective tissue and extracellular matrix (ECM) deposition that precludes normal healing processes of different tissues. Connective tissue growth factor (CTGF) seems to be involved in the fibrotic response. Several muscular dystrophies are characterized by a progressive weakness and wasting of the musculature, and by extensive fibrosis. However, the exact role of CTGF in skeletal muscle is unknown. Here we show that myoblasts and myotubes are able to synthesize CTGF in response to transforming growth factor type-beta (TGF-beta) and lysophosphatidic acid (LPA). CTGF induced several ECM constituents such as fibronectin, collagen type I and alpha4, 5, 6, and beta1 integrin subunits in myoblasts and myotubes. CTGF had an important inhibitory effect on muscle differentiation evaluated by the decrease in the nuclear translocation of the early muscle regulatory factor myogenin and myosin. Remarkable, CTGF treatment of myoblasts induced their dedifferentiation, characterized by down regulating MyoD and desmin, two markers of committed myoblasts, together with a strong reorganization of cytoskeletal filaments. These results provide novel evidence for the underlying mechanisms and participation of skeletal muscle cells in the synthesis and role of CTGF inducing fibrosis, inhibiting myogenesis and dedifferentiating myoblasts.
机译：纤维化疾病被过度的典型结缔组织和细胞外基质(ECM)沉积,导致无法正常愈合不同组织的过程。生长因子(CTGF)似乎是参与纤维化反应。特点是累进的弱点和浪费的肌肉组织,广泛纤维化骨骼肌是未知的。成肌细胞和肌管能够合成CTGF在回应转化生长因子type-beta(及)和lysophosphatidic酸(LPA)。纤连蛋白、胶原蛋白I型和alpha4, 5, 6,和beta1整合素亚单位在成肌细胞肌管。在肌肉分化的评估减少的核易位早期肌肉myogenin和监管因素肌凝蛋白。诱导他们去分化的特征调节MyoD和肌间线蛋白,两个的标志成肌细胞,加上强劲细胞骨架纤维的重组。结果提供了底层的新证据骨骼肌的机制和参与细胞合成和CTGF诱导的作用纤维化,抑制肌细胞生成去分化成肌细胞。

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