Structure and function of 2:1 DNA polymerase.DNA complexes.

Tang KH; Tsai MD

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Structure and function of 2:1 DNA polymerase.DNA complexes.

机译：2:1 DNA聚合酶的结构和功能。复合物。

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DNA polymerases are required for DNA replication and DNA repair in all of the living organisms. Different DNA polymerases are responsible different stages of DNA metabolism, and many of them are multifunctional enzymes. It was generally assumed that the different reactions are catalyzed by the same enzyme molecule. In addition to 1:1 DNA polymerase.DNA complex reported by crystallization studies, 2:1 and higher order DNA polymerase.DNA complexes have been identified in solution studies by various biochemical and biophysical approaches. Further, abundant evidences for the DNA polymerase-DNA interactions in several DNA polymerases suggested that the 2:1 complex represents the more active form. This review describes the current status of this emerging subject and explores their potential in vitro and in vivo functional significance, particularly for the 2:1 complexes of mammalian DNA polymerase beta (Pol beta), the Klenow fragment of E. coli DNA polymerase I (KF), and T4 DNA polymerase.

机译：DNA聚合酶DNA复制所必需的并在所有的生物体DNA修复。不同的DNA聚合酶是负责任的DNA代谢的不同阶段,许多多功能酶。普遍认为,不同的反应由相同的酶分子催化。除了1:1 DNA聚合酶。结晶的研究报道,2:1高阶DNA聚合酶。被确定在各种解决方案的研究生物化学和生物物理方法。DNA polymerase-DNA丰富的证据相互作用在几个DNA聚合酶2:1复杂代表更活跃的形式。这一新兴学科和探索潜在的体外和体内的功能意义,尤其是2:1的复合物哺乳动物的DNA聚合酶β(Polβ)大片段的大肠杆菌DNA聚合酶(KF),和T4 DNA聚合酶。

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来源
《Journal of Cellular Physiology》 |2008年第2期|315-320|共6页
作者
Tang KH; Tsai MD;
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作者单位

Department of Chemistry, The Ohio State University, Columbus, Ohio, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
DNA-Directed DNA Polymerase; DNA Polymerase I; DNADNA RepairDNA metabolismBinding SitesMacromolecular Substances;

机译：DNA-Directed DNA聚合酶;DNA聚合酶我,DNADNA RepairDNA metabolismBindingSitesMacromolecular物质;

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Structure and function of 2:1 DNA polymerase.DNA complexes.

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