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首页> 外文期刊>Journal of Cellular Physiology >Biomolecular characterization of human glioblastoma cells in primary cultures: differentiating and antiangiogenic effects of natural and synthetic PPARgamma agonists.
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Biomolecular characterization of human glioblastoma cells in primary cultures: differentiating and antiangiogenic effects of natural and synthetic PPARgamma agonists.

机译：生物分子特征的人类胶质母细胞瘤细胞主要文化:区分和抗血管新生的影响天然和合成PPARgamma受体激动剂。

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摘要

Gliomas are the most commonly diagnosed malignant brain primary tumors. Prognosis of patients with high-grade gliomas is poor and scarcely affected by radiotherapy and chemotherapy. Several studies have reported antiproliferative and/or differentiating activities of some lipophylic molecules on glioblastoma cells. Some of these activities in cell signaling are mediated by a class of transcriptional factors referred to as peroxisome proliferator-activated receptors (PPARs). PPARgamma has been identified in transformed neural cells of human origin and it has been demonstrated that PPARgamma agonists decrease cell proliferation, stimulate apoptosis and induce morphological changes and expression of markers typical of a more differentiated phenotype in glioblastoma and astrocytoma cell lines. These findings arise from studies mainly performed on long-term cultured transformed cell lines. Such experimental models do not exactly reproduce the in vivo environment since long-term culture often results in the accumulation of further molecular alterations in the cells. To be as close as possible to the in vivo condition, in the present work we investigated the effects of PPARgamma natural and synthetic ligands on the biomolecular features of primary cultures of human glioblastoma cells derived from surgical specimens. We provide evidence that PPARgamma agonists may interfere with glioblastoma growth and malignancy and might be taken in account as novel antitumoral drugs.
机译：神经胶质瘤是最常见的诊断恶性的大脑的主要肿瘤。高级神经胶质瘤是贫穷和几乎没有影响放疗和化疗。抗增殖和/或报告吗区分一些lipophylic活动分子在胶质母细胞瘤细胞。活动由一个细胞信号传导等类转录因子称为过氧物酶体proliferator-activated受体(PPARs)。改变了人类的起源和它的神经细胞已经证明PPARgamma受体激动剂吗减少细胞增殖,促进细胞凋亡和诱导形态变化和表达式标记的典型的分化在胶质母细胞瘤和星形细胞瘤细胞表型行。进行长期培养转化细胞行。长期以来在体内环境中繁殖文化往往导致的积累进一步的分子细胞的变化。尽可能接近体内条件下,现在我们调查的影响PPARgamma天然和合成配体生物分子特性的基本文化人类胶质母细胞瘤细胞来自手术标本。受体激动剂可能会干扰胶质母细胞瘤的生长恶性肿瘤和可能采取的帐户小说antitumoral药物。

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