Regulation of insulin receptor substrate-1 expression levels by caveolin-1.

Chen J; Capozza F; Wu ADeangelis TSun HLisanti MBaserga R

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Regulation of insulin receptor substrate-1 expression levels by caveolin-1.

机译：调节胰岛素受体底物由caveolin-1表达水平。

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The insulin receptor substrate-1 (IRS-1), a docking protein of the type 1 insulin-like growth factor receptor (IGF-IR) plays a significant role in cell proliferation and differentiation. The expression of IRS-1 is down-regulated in mouse embryo fibroblasts (MEFs) with a deletion of caveolin-1 (cav1) genes (KO cells). Levels of IRS-1 mRNA are not affected. Re-introduction of cav1 into KO cells rescues IRS-1 expression. Stabilization of protein levels is reciprocal and a strict correlation between IRS-1 and cav1 levels was confirmed in five cell lines, and in mouse tissues. IRS-1 binds through its phosphotyrosine binding (PTB) domain to tyrosine 14 (Y14) of cav1, the residue phosphorylated by IGF-1 stimulation and by v-src. The down-regulation of IRS-1 in cav-/- cells occurs via the proteasome pathway. These results indicate a novel mechanism for the regulation of IRS-1 expression levels, an important finding in view of IRS-1 role in cell proliferation and transformation.

机译：胰岛素受体底物(IRS-1)对接1型胰岛素样生长的蛋白质因子受体(IGF-IR)中起着重要作用在细胞增殖和分化。IRS-1抑制在老鼠的表情胚胎成纤维细胞(mef)删除caveolin-1 (cav1)基因(KO细胞)。IRS-1 mRNA不受影响。cav1 KO细胞救援IRS-1表达式。是互惠的,稳定的蛋白质水平一个严格的相关性IRS-1和cav1水平被确认在5细胞株,在老鼠的组织。phosphotyrosine绑定(PTB)域酪氨酸14 (cav1 Y14)、残基磷酸化igf - 1刺激和v - src。下调IRS-1 cav - / -细胞的发生通过蛋白酶体途径。指出小说的监管机制IRS-1表达水平,一个重要的发现在细胞增殖和IRS-1的作用转换。

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来源
《Journal of Cellular Physiology》 |2008年第1期|281-289|共9页
作者
Chen J; Capozza F; Wu ADeangelis TSun HLisanti MBaserga R;
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作者单位

Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, Pennsylvania, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
CAV1 gene; Cell Line; Proteasome Endopeptidase ComplexblottingInsulin-Like Growth Factor ReceptorRegulation (biology)PTB DomainCell ProliferationCaveolin 1insulin receptor substrate 1Adaptor Signaling Protein;

机译：CAV1基因;细胞系;蛋白酶体肽链内切酶ComplexblottingInsulin-Like生长因子ReceptorRegulation肺结核DomainCell(生物学)ProliferationCaveolin 1胰岛素受体底物1适配器信号蛋白;

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Regulation of insulin receptor substrate-1 expression levels by caveolin-1.

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