...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >The mesenchymal stromal cell contribution to homeostasis.
【24h】

The mesenchymal stromal cell contribution to homeostasis.

机译：间充质基质细胞的贡献体内平衡。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adult mesenchymal stromal cells (MSCs) are undifferentiated multi-potent cells predominantly residing in the bone marrow (BM), but also present with similar but not identical features in many other tissues such as blood, placenta, dental pulp, and adipose tissue. MSCs have the potential to differentiate into multiple skeletal phenotypes like osteoblasts, chondrocytes, adipocytes, stromal cells, fibroblasts, and possibly tendons. MSCs differentiation potential, ex vivo expansion capacity, nurturing and immunomodulatory proficiencies oriented these versatile cells in several areas of ongoing clinical applications. However, the absence of MSC-specific markers for isolation and characterization together with the lack of a comprehensive view of the molecular pathways governing their particular biological properties, remains a primary obstacle to their research and application. In this review we discuss some areas of growing interest in MSCs biology: their contribution to the hematopoietic stem cell (HSC) niche, to regenerative medicine, their role in cancer and in therapy as delivery tools and their micro-RNA (miRNA) signatures. Despite rapid progress in the MSC field, it is generally thought that only a fraction of their full potential has been realized thus far.
机译：成人间充质基质细胞(msc)未分化的多能细胞为主居住在骨髓(BM),但也相似但不相同的特性在许多其他组织如血液、胎盘牙髓和脂肪组织。潜在的分化成多个骨骼表型与成骨细胞、软骨细胞脂肪细胞、基质细胞、成纤维细胞和可能是肌腱。体外扩张能力,培育和免疫调节熟练程度的这些多功能细胞在一些地区正在进行的临床应用。MSC-specific隔离和标记描述与缺乏全面的分子途径管理他们的特定的生物学性质,他们的研究,仍然是一个主要障碍应用程序。越来越感兴趣的msc生物学:他们对造血干细胞(HSC)的贡献利基,再生医学,他们的作用在治疗癌症和交付工具和他们的微核糖核酸(microrna)签名。MSC领域的进展,它一般认为只有他们的完整的一小部分可能已经意识到目前为止。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号