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首页> 外文期刊>Journal of Cellular Physiology >Dystroglycan expression is reduced during prostate tumorigenesis and is regulated by androgens in prostate cancer cells.
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Dystroglycan expression is reduced during prostate tumorigenesis and is regulated by androgens in prostate cancer cells.

机译：在前列腺Dystroglycan表达减少肿瘤发生和受雄激素前列腺癌的细胞。

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Prostate cancer, the most frequently diagnosed cancer in Western men, can display a high variability in term of clinical aggressiveness and prognosis and none of the available markers is able to accurately predict its clinical course. Dystroglycan (DG), a non-integrin adhesion molecule, is a complex formed by two subunits, alpha- and beta-DG, which bind to extracellular matrix molecules and cytoskeleton, respectively. DG expression is frequently reduced in human cancers and has been related to tumor grade and aggressiveness. This study investigated the role of DG in human prostate tumorigenesis and its suitability as a prognostic marker. The expression level of extracellular alpha-DG subunit was frequently reduced in human prostate cancer cell lines and primary tumors and the percentage of positive tumor cells was significantly further decreased in vivo following androgen ablation therapy (median = 1%) compared to pre-treatment samples (median = 28%). A significant relationship was observed between alpha-DG staining on the post-treatment samples and tumor recurrence. A dose- and time-dependent decrease of DG expression also occurred in human prostate cancer cells following treatment with the anti-androgen flutamide. Stable expression of an exogenous DG cDNA in the LNCaP human prostate carcinoma cell line resulted in a marked inhibition of both anchorage-dependent and independent growth and of the in vivo tumorigenicity. These findings confirm and extend previous evidence that disturbances in the function of the DG complex might contribute to the definition of the malignant behavior of prostate cancer cells and suggest that androgens might regulate DG expression in these cells.
机译：前列腺癌最常见的诊断癌症在西方男人,可以显示一个高变化的临床攻击性和预后,没有可用的标记能够准确地预测其临床课程。粘附分子,是一个复杂的由两个子单元,α-和beta-DG绑定细胞外基质分子和细胞骨架,分别。在人类癌症和肿瘤有关年级和侵略性。DG在人类前列腺肿瘤发生的作用作为一个预后标记及其适用性。细胞外alpha-DG的表达水平亚基是经常减少人类前列腺癌癌症细胞系和原发性肿瘤积极的肿瘤细胞的比例进一步显著降低体内(中位数= 1%)接受雄激素阻断疗法进行比较预处理样品(值= 28%)。重要的关系观察alpha-DG染色后处理的样本和肿瘤复发。减少DG表达式也发生在人类治疗后前列腺癌细胞在长达flutamide。的外生DG cDNA LNCaP人类前列腺癌癌细胞系导致显著anchorage-dependent和抑制独立生长和体内致瘤性。以前的证据表明的干扰DG复杂的函数可能会导致的恶性行为的定义前列腺癌细胞和表明雄激素可能在这些细胞调节DG的表达。

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  • 1. PROSTATE CANCER GEN. [P] . 外国专利： ES2190925T3 . 2003-09-01

    机译：prostate cancer gen.

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